POS0105 CHANGES IN RADIOGRAPHIC SIGNS IN PATIENTS WITH HAND OSTEOARTHRITIS DURING 2 YEARS
Notice bibliographique
Résumé
Background Hand osteoarthritis is a disorder that often evolves slowly. Some patients may have structural progression over a short term. Objectives We aimed to investigate which patients show radiographic progression over 2 years and what their determinants are. Methods Data from the ongoing HOSTAS (Hand OSTeoArthritis in Secondary care) cohort were used, consisting of 538 consecutive patients with primary hand OA diagnosed by their rheumatologist, followed for two years. Hand radiographs were obtained at baseline and year two. Questionnaires regarding demographics, disease and patient characteristics and the Australian Canadian Hand osteoarthritis index (AUSCAN) were collected. Hand radiographs were scored blinded, paired and in chronological order, using the Osteoarthritis Research Society International (OARSI) system (osteophytes (OP) and joint space narrowing (JSN), scored 0-3) per joint (summed for total 0-96). Intraobserver reliability was high, (intra-class correlation (ICC) 0.99 and 1.00 at baseline for OP and JSN sumscores, respectively). Reliability for change scores was high (ICC 0.77 and 0.86, for OP and JSN, respectively). The smallest detectable changes were 0.92 for OP (cut-off 1) and 1.32 for JSN (cut-off 2). Cut-offs were used to classify progressors (increase) or non-progressors (stable or decrease). Additionally, baseline radiographs were scored using the Kellgren-Lawrence system (0-4 per joint, total 0-120). Erosive disease was defined as at least 1 joint in the Verbruggen-Veys erosive or remodeling phase. Progressor and non-progressor groups were analysed for determinants using logistic regression. Results 442 patients had radiographs assessed at baseline and year 2, with mean (SD) age 61 (8.4) years and 85% female. Median (IQR) baseline OP/JSN sumscores were 9 (5-18) and 9 (4-19), respectively. Based on the SDC, 272/417 (65%) participants progressed on OP scores (median [IQR] change 1 [0-2]) and 135/419 (32%) on JSN scores (median [IQR] change 1 [0-2]). Four and 18 had a decrease in OP and JSN, respectively. Progression of OP was positively associated with erosive disease, measures of radiographic damage at baseline and female sex. Progression of JSN was positively associated with age, erosive disease and radiographic damage at baseline. Progression of JSN showed a positive association with changes in AUSCAN scores over 2 years. Conclusion Over 2 years, considerable radiographic progression was seen. Especially patients with erosive disease and the most severe radiographic damage at baseline were at risk for progression. Progression of JSN was associated with changes in pain and function. Progression in JSN was associated with age, whereas OP was with female sex. These findings may potentially represent different underlying pathogenetic mechanisms. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests Coen van der Meulen Grant/research support from: The HOSTAS study is supported by a grant from the Dutch Arthritis Society, paid to the institution, Lotte van de Stadt: None declared, Frits Rosendaal: None declared, Sjoerd van Beest: None declared, Margreet Kloppenburg Grant/research support from: The HOSTAS study is supported by a grant from the Dutch Arthritis Society, paid to the institution.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».