POS1366 EFFICACY OF DULOXETINE COMPARED TO NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN THE TREATMENT OF KNEE OSTEOARTHRITIS IN IRAQI KURDISTAN REGION
Notice bibliographique
Résumé
Background Osteoarthritis (OA) is the most common degenerative joint disease [1]. Knee OA is an insidious disease related to structural changes in the joint over many years. Duloxetine, a selective serotonin, and norepinephrine reuptake inhibitor, seems to be effective in treating neuropathic and chronic pain conditions [6]. Objectives The objective of this study was to assess the efficacy of duloxetine tablet compared to nonsteroidal anti-inflammatory (NSAID) for the reduction of pain in Osteoarthritis. Methods A Randomized open labelled clinical trial of a 13-weeks done in Rizgary Teaching and CMC (Consultant Medical City) hospitals in Iraqi Kurdistan Region. From 5th of September 2022 to 2nd of January 2023 with Trial Registration ID (NCT05486026). Those eligible to enter the study their ages were ≥ 40years, both Genders were included, who will meet the American College of Rheumatology clinical and radiographic criteria for the diagnosis of osteoarthritis of the knee [8]. Patients were divided into two groups, The first group received Duloxetine tablet 30 mg for two weeks then titrated up to 30 mg BID. were compared to control group that received NSAID (nonsteroidal anti-inflammatory drug). End points were recorded at baseline then 2nd visits at 13 weeks. Measurement of pain severity was done by the weekly mean of the 24-h average pain scores in patients with osteoarthritis knee pain by Brief pain inventory (BPI). Another tool is (WOMAC) WESTERN ONTARIO AND MCMASTER OSTEOARTHITIS INDEX used for evaluation of pain in knee Osteoarthritis which involve three categories. The Patient Global Impression of Improvement (PGI-I) scale measured patients’ perceived change in overall well-being (in response to therapy/treatment) and even side effects. Results Out of two hundred patients, forty-six participants were excluded: one hundred fifty-four were enrolled in the study. Their mean ages ±SD (57.38 ±10.58, 58.47±12.03) in Duloxetine, NSAID group Respectively. BPI-Severity average pain improved significantly after treatment with Duloxetine were 4.64 (95%CI:4.25 to 5.02) and P value was 0.00. BPI during 24-hour pain interfere with (activity, Mood, walking ability, work, relations with other people, sleep, enjoyment of life) were lower in Duloxetine group after treatment in comparison to control group (NSAID) 4.45 (95% CI:4.01 to 4.87), 5.47 (95%CI:5.11 to 5.82) respectively p value was significant ‹ 0.001. The total WOMAC score after treatment in Duloxetine group decreased 31.74 (95%CI:27.05 to 36.42) while in NSAID groups were 42.46(95%CI:38.05 to 46.86). about (PGI-I) scale, the patients who treated with Duloxetine was generally better than those treated with NSAID group; as the response and cure rate were higher in the Duloxetine(34.2%,30.3%,7.9%) much improve, very much improved, minimally improved respectively so; total (72.4%) were improved in comparison to the control group(28.2%, 6.4%, 11.5%) much improved, much improved,minimally improved respectively so; total (46.1%) were improved, the p value were significant 0.002 and about adverse effect in Duloxetine group most common side effects were epigastric pain and headache(3,3), with one patient with nausea, one with tremor and one fatigability, the symptoms were mild they continue study with symptomatic treatment of side effects, and 4 in NSAID developed side effect. Conclusion Duloxetine reduced pain and improved function in patients with knee osteoarthritis, by reducing BPI inventory and WOMAC score, with much improvement on PGI scales in comparison to NSAID. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests None Declared.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».