ONKOFRAIL: PERSONALIZATION OF A PHYSICAL EXERCISE PROGRAM IN OLDER PATIENTS WITH LYMPHOMA
Notice bibliographique
Résumé
Several authors highlight the importance of including a physical exercise program during and after cancer treatment, based on the positive effects shown by several studies in young patients. However, there is very little evidence on the effects of physical exercise during cancer treatment in older patients with lymphoma. Recommendations of different scientific societies are based on the expert’s opinion and studies with younger patients with non-hematological cancer. Therefore, this is an unknown area and it is a priority to promote research projects in order to generate effective interventions for this population. Different studies in cancer patients have shown that physical exercise reduces loss of functionality, attenuates frailty during cancer treatment, reduces toxicity and improves treatment completion rate. Recent studies have shown that physical exercise during chemotherapy is safe and that it may benefit in reducing toxicity and maintaining physical and mental well-being. For all these reasons, this research study analyzes the role of supervised physical exercise in older people with lymphoma in an innovative way, with the aim of generating new hypotheses that overcome existing limitations and facilitate the introduction of this type of intervention in the health system. For this purpose, a randomized controlled multicenter study has been designed. All patients over 70 years of age diagnosed with lymphoma who require systemic treatment will be invited to participate. The control group will receive the usual care and movement hygiene recommendations, while the intervention group will add an individualized, progressive, moderate-intensity, supervised physical exercise program of 12 weeks duration, with the content described in Figure 1. All eligible patients will be assessed before receiving a systematic treatment and after 12 weeks. The Comprehensive Geriatric Assessment (CGA) will assess comorbidity, functional capacity, and nutritional status, emotional/cognitive and social status. The evaluation also includes the SPPB test (Short Physical Performance Battery) the Fried Frailty Phenotype, the 8 foot up and go and Steep Ramp Test, the Montreal Cognitive Assessment (MoCA test), PROs (patient reported outcomes) and the level of physical activity and sedentary behavior measured by accelerometer. The study will also analyze certain biomarkers associated with vulnerability that provide objective information complementary to the clinical assessment and allow a more robust stratification of these patients. This study was approved by the Committee on Drug Research Ethics (CEIm) of the Basque Country (Euskadi). The Trial is ongoing and we have already included 17 patients. The research was funded by: Biodonostia Keyword: ongoing trials No conflicts of interests pertinent to the abstract.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».