Relationship between Sleep Disturbances and In Vitro Fertilization Outcomes in Infertile Women: A Systematic Review and Meta-Analysis
Notice bibliographique
Résumé
Abstract Background and Aim: Infertility means failure to achieve a clinical pregnancy after 12 months of regular unprotected intercourse or reproductive disorders. In this respect, in vitro fertilization has been acknowledged as the primary assisted reproductive technology technique for the fertilization of oocytes outside the female reproductive system, which is steadily increasing thanks to its prenatal safety. However, stress and anxiety, inextricably linked to sleep disorders, are likely to affect infertility and its treatment. Against this background, the present study was to investigate the relationship between sleep disturbances and IVF outcomes in infertile women. Materials and Methods: Considering no language limits, the databases of PubMed (1996), Embase (1980), the Cochrane Library (2010), ProQuest (1995), and Web of Science (1997) were searched for the relevant articles published up to April 2023. The Newcastle-Ottawa Scale was then used to assess their methodological quality. Moreover, the random effects model and the STATA (v.11) software program were utilized to present the odds ratio with 95% confidence interval. Ultimately, the Begg’s test and funnel plots were recruited to examine publication bias and sensitivity analysis, thereby determining the impact of each study on its final results. Findings: During the initial search, 425 articles were retrieved; however, five studies remained after the exclusion of the unrelated ones, including two and three cross-sectional and cohort studies, respectively. The review findings demonstrated that sleep disturbances were more common in women undergoing the IVF techniques than the general population. In addition, such disorders were associated with getting pregnant, oocyte retrieval, ovulation, live birth, and fetal weight. After combining the ORs reported in the cross-sectional studies with 95% CI based on the I2 index (OR=0.42, 95% CI=[0.23, 0.60], I2=0.0%) and the p-value of 0.901 for heterogeneity according to the fixed effects model, the relationship between sleep and pregnancy was approved. On the other hand, upon combining the ORs revealed in the cohort studies with 95% CI based on the I2 index (OR=1.02, 95% CI=[0.86, 1.18], I2=77.9%) and the p-value of 0.011 for heterogeneity with reference to the random effects model, the relationship between sleep and pregnancy was not confirmed. Results: The study results established that sleep, as a modifiable parameter, could affect IVF outcomes. Therefore, health policymakers must develop effective interventions for the youth population along with childbearing policies to improve sleep as an important factor.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,008 | 0,022 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,001 |
| Méta-épidémiologie (sens large) | 0,016 | 0,025 |
| Bibliométrie | 0,007 | 0,008 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,003 | 0,001 |
| Science ouverte | 0,002 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».