Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory
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Neuroscience review synthesizing engram mechanisms across memory encoding, consolidation, retrieval, and forgetting; the object is memory biology.
This review synthesizes neurobiological knowledge about memory engrams rather than studying research itself.
Neuroscience review of memory engram mechanisms; object is brain function, not research practice.
Résumé
Tremendous strides have been made in our understanding of the neurobiological substrates of memory - the so-called memory "engram". Here, we integrate recent progress in the engram field to illustrate how engram neurons transform across the "lifespan" of a memory - from initial memory encoding, to consolidation and retrieval, and ultimately to forgetting. To do so, we first describe how cell-intrinsic properties shape the initial emergence of the engram at memory encoding. Second, we highlight how these encoding neurons preferentially participate in synaptic- and systems-level consolidation of memory. Third, we describe how these changes during encoding and consolidation guide neural reactivation during retrieval, and facilitate memory recall. Fourth, we describe neurobiological mechanisms of forgetting, and how these mechanisms can counteract engram properties established during memory encoding, consolidation, and retrieval. Motivated by recent experimental results across these four sections, we conclude by proposing some conceptual extensions to the traditional view of the engram, including broadening the view of cell-type participation within engrams and across memory stages. In collection, our review synthesizes general principles of the engram across memory stages, and describes future avenues to further understand the dynamic engram.
Conservé avec la notice de tri, où il sert de preuve aux étiquettes ci-dessus.
La notice
- Revue
- Molecular Psychiatry
- Thématique
- Memory and Neural Mechanisms
- Domaine
- Neuroscience
- Établissements canadiens
- University of British Columbia HospitalUniversity of British Columbia
- Organismes subventionnaires
- Canadian Institutes of Health ResearchNatural Sciences and Engineering Research Council of CanadaGovernment of Canada
- Mots-clés
- EngramForgettingMemory consolidationEncoding (memory)NeuroscienceRecallPsychologyConsolidation (business)MemorizationLong-term memoryCognitive scienceCognitive psychologyHippocampusCognition
- Résumé présent dans OpenAlex
- oui