Prevalence of depression and anxiety symptoms by liver disease etiology

Health care providers who care for patients with liver disease (LD) often come to learn that psychiatric comorbidities, such as depression (DEP) and anxiety (ANX) symptoms, are prevalent within this population. Over the past 10–15 years, a growing body of literature has provided evidence to support the association between LD and the presence of DEP and/or ANX.1–5 These findings are often embedded within a heterogeneous mix of studies examining the association(s) between LD and health-related quality of life, predictors of increased morbidity and mortality among these patients, or clinical outcomes measured as part of liver transplant.1–5 The prevalence rates of DEP and ANX reported by many investigations also widely vary due to differences in the screening instruments and diagnostic thresholds used to define clinically relevant affective symptoms. For example, the prevalence of DEP symptoms in patients diagnosed with chronic LD was 63% in studies using self-report inventories, with far lower rates (4.5%) observed in studies using diagnostic clinical interviews.2 This brief review aims to summarize the prevalence of both DEP and ANX symptoms in patients with LD, paying particular attention to screening measures and diagnostic thresholds used across studies. In addition, prevalence rates seem to vary across different etiology and histologic staging of LD. ALCOHOL-ASSOCIATED LIVER DISEASE (ALD) DEP and ANX symptoms are highly prevalent in patients with alcohol use disorders,4 and there is evidence to support an association between these comorbidities (Table 1). Rogal and colleagues reported the prevalence of ICD-9 DEP diagnoses to be 22% in patients with alcohol-associated liver disease (ALD) before liver transplant. Further, pretransplant DEP was also associated with post-transplant survival rates, length of hospitalization, and discharge to an outside facility.8 In a prospective cohort study of 51 patients with ALD waitlisted for transplant,6 the prevalence of self-report DEP and ANX symptoms was reported as 37.3% and 43.1%, respectively. TABLE 1 - DEP and ANX in patients with ALD References, country Study design ALD patient (N) Comparison group (N) Assessment and cut-score Prevalence DEP Prevalence ANX Annema et al6Netherlands Prospective cohort 51 — STAI, ≥ 12 CES-D, ≥16 37.3 43.1 DiMartini et al7US Prospective longitudinal 167 — DSM-IV Diagnoses 20 13 Rogal et al8 US Retrospect-analysis 46 ALD w/DEP 162 ALD w/o DEP ICD-9 diagnoses 22% vs. 19% — Santos et al9Brazil Prospective <80a — BAI, ≥ 8 — 29% with mild, moderate, or severe ANX Note: Italicized = Studies that reported the prevalence of ANX, either in combination with- or independent of the prevalence of DEP.aThis study did not provide the N of patients with ALD, but instead indicated HCV to be the modal etiology of LD with N = 80 patients.Abbreviations: BAI, Beck Anxiety Inventory; CES-D, Center for Epidemiological Studies Depression Scale; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; ICD-9, International Classification of Disease, Ninth Edition; STAI, State-Trait Anxiety Inventory. As part of a prospective longitudinal study, DiMartini and colleagues reported the lifetime prevalence of clinical DEP and ANX, per DSM-IV criterion, to be 20% and 13%, respectively, among 167 patients with ALD before liver transplant. The authors also showed that the lifetime prevalence of clinical DEP was the strongest predictor of survival, conferring a 2-time higher risk of mortality among patients with ALD.7 In one of the only studies to exclusively examine self-reported ANX among patients with ALD awaiting transplant, Santos and colleagues reported the prevalence of ANX symptoms to be 29%. NONALCOHOLIC FATTY LIVER DISEASE NAFLD is the hepatic manifestation of metabolic syndrome. It is well established that DEP is associated with aspects of metabolic syndrome (eg, obesity).10 Similarly, a growing body of research supports the association between NAFLD and increased DEP, though far fewer studies report on the prevalence of ANX among patients with NAFLD1 (Table 2). TABLE 2 - DEP and ANX in patients with NAFLD References, country Study design NAFLD patient (N) Comparison group (N) Assessment and cut-score Prevalence DEP Prevalence ANX Jung et al11 Korea Cross-sectional 112,797 — CES-D ≥ 16 11.1% (FLI—normal) — — — — — 8.9% (FLI—mild) — — — — — 9.7% (FLI—Mod/severe) — Weinstein et al12 US Cross-sectional 184 190 HBV504 HCV Self-Report+ MR Confirm 27.2% NAFLD3.7% HBV29.8% HCV — Xiao et al13 Singapore Meta-analysis 2,041,752 — Various 18.2% pooled estimate — Youssef et al14US Cross-sectional 567 — HADS-D (1–7, ≥ 8) HADS-A (1–7, ≥8) 14% (clinical ≥8) 53% (Subclinical 1–7) 25% (clinical ≥8) 45% (subclinical 1–7) Note: Italicized = Studies that examined both depression and anxiety symptoms.Abbreviations: CES-D, Center for Epidemiological Studies Depression Scale; FLI, Fatty Liver Index; HADS, Hospital Anxiety and Depression Scale; MR, medical record. Xiao and colleagues reported the pooled prevalence of DEP to be 18.2% across 11 studies using NAFLD samples. Several cross-sectional investigations of patients with NAFLD also report on the prevalence of DEP and ANX, though rates widely vary. For example, Weinstein and colleagues reported the prevalence of DEP to be 27.2% in NAFLD when using self-reported diagnoses paired with confirmatory medical record review. Further, patients with NAFLD were shown to have a significantly higher prevalence of DEP compared with those with hepatitis B (HBV; 3.7%) but not hepatitis C (29.8%).12 In a large population-based study of 567 patients with NAFLD,14 Youssef and colleagues showed that 14% of patients endorsed moderate to severe DEP on the Hospital Anxiety and Depression Scale (HADS), while 53% reported subclinical/mild symptoms of DEP. Similar findings were also shown for ANX, as 25% of patients with NAFLD reported moderate/severe symptoms, while 45% reported subclinical ANX symptoms.14 Evidence also supports an association between DEP/ANX and the histological staging of NAFLD. For example, Youssef and colleagues reported that patients endorsing moderate/severe DEP were 3.6 times more likely to present with more severe NAFLD compared with patients endorsing subclinical/no DEP. This finding was also observed in a large, population-based study of 112,797 Korean men and women, whereby the severity of NAFLD was significantly associated with self-reported DEP, even after covariate adjustment.11 Regarding ANX, Choi and colleagues reported that the prevalence of both state- and trait-ANX (ie, here state-ANX is defined as ANX one feels in the moment while trait-ANX is ANX one generally feels overall) increased in patients with more severe NAFLD, but only among women.15 HCV-RELATED LD DEP and ANX symptoms are known to be prevalent in patients with HCV,16 and they often occur at a higher rate compared to patients with HBV or healthy controls.17–19 In a meta-analysis of 12 studies that included 130,039 patients,19 the pooled prevalence of DEP was 24.5% among those diagnosed with HCV compared with 17.2% of non-HCV controls (Table 3). The authors also reported that patients with HCV had twice the risk of DEP compared with healthy controls.19 Carta and colleagues showed the lifetime prevalence of major depressive disorder (MDD), assessed through structured clinical interview, was 32.6% for HCV, 15.5% for HBV, and 12.8% for healthy controls. Similarly, the lifetime prevalence of panic disorder was 8.9% for patients with HCV compared with 7.9% for HBV and 2.8% for healthy controls. Associations between HCV and generalized ANX disorder or social phobia were not significant.17 Two population-based studies in the United States18 and Germany20 reported the prevalence of DEP as 29.7% and 25.9%, respectively, though neither survey investigation measured ANX. TABLE 3 - DEP and ANX in patients with HCV-related LD References, country Study design HCV patient (N) Comparison group (N) Assessment and cut-score Prevalence DEP Prevalence ANX Boscarino et al18 US Cross-sectional 4781 — PHQ-8, ≥ 10 29.7% — Carta et al17Italy Cross-sectional 135 76 HBV 540 control CIDI 32.6% lifetime-HCV 15.1% lifetime-HBV 12.8% lifetime-control 8.9% lifetime panic-HCV 7.9% lifetime panic-HBV 2.8% lifetime panic-control Erim et al20 Germany Cross-sectional 81 — BDI, ≥14HADS-A, ≥7 25.9% — Gallach et al21Spain Intervention 145 — HADS ≥7 13.1% at baseline 8.3% at baseline Schaefer et al22 Review — — Various 30%–70% 15%–45% MDD 11%—45% Younossi et al19 Meta-analysis 130,039 127,506 Various 24.5% pooled estimate17.2% of non-HCV controls — Note: Italicized = Studies that examined both DEP and ANX.Abbreviations: BDI, Beck Depression Inventory; CIDI, Composite International Diagnostic Interview; GADI, Generalized Anxiety Disorder Inventory; HADS, Hospital Anxiety and Depression Scale; INF, Interferon (INF)-alpha treatment; PHQ-8, Patient Health Questionnaire, 8-Item Version. Historical data have shown that interferon (INF)-based antiviral therapy for patients with HCV is frequently associated with treatment-induced DEP and ANX.22 Schaefer and colleagues reported the prevalence of DEP during INF treatment to be 30%–70% based on 10 studies, though prevalence rates varied by type of screening instrument. For example, it was estimated that MDD developed in 15%–45% of patients treated with INF,22 as assessed by diagnostic interview. Similarly, the authors estimated the prevalence of ANX during INF treatment to be 11%–45% across 7 studies.22 However, when comparing the prevalence rates of DEP and ANX between INF and direct-acting antiviral agents in patients with HCV, research suggests that direct-acting antiviral agents do not seem to be associated with treatment-inducted DEP or ANX.21 Gallach and colleagues showed that the prevalence of self-reported baseline DEP and ANX was 13.1% and 8.3%, respectively. However, no differences in DEP and ANX rates were found either during or after 12-week direct-acting antiviral agent treatment, suggesting that this antiviral therapy did not significantly impact psychological symptoms during the trial or after sustained virologic response.21 OTHER ETIOLOGIES OF LD This brief review also considers DEP and ANX across several other etiologies of LD: primary biliary cholangitis, primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH), and HBV (Table 4). TABLE 4 - DEP and ANX in patients with other etiologies of chronic LD References, country Study design Etiology LD patient (N) Comparison group (N) Assessment and cut-score Prevalence DEP Prevalence ANX Huang et al23 China Prospective 209 HBV — HAM-D ≥ 20 5.3% — — — — HAM-D 7-19 23.9% — Huet et al24 Canada Cross-sectional 116 PBC — BDI ≥10 44.8% — Janik et al25Poland Cross-sectional 140 AIH 170 healthy PHQ-9 STAI 29% w/ moderate to severe symptoms Measured, but rates not reported van Os et al26 Netherlands Cross-sectional 92 — BDI ≥10 42% — — PBC and PSC — DSM-IV — — — — — MDD 3.7% — Schramm et al27Germany Cross-sectional 103 AIH 1939 Healthy PHQ-9 5.9% w/DEP symptoms 8.3% w/ moderate ANX — — 3720 Healthy GAD-7 10.8% w/ MDD 4.2% w/ severe ANX Yilmaz et al28Turkey Cross-sectional 41 HBV 36 inactive HBV and 53 healthy HADS-D > 10 60% HBV 48.7% HBV — — — HADS-A > 8 47.2% inactive HBV 33.5% inactive HBV — — — — 25% Healthy 20.7% Healthy Note: Studies that examined both DEP and ANX.Abbreviations: AIH, autoimmune hepatitis; BDI, Beck Depression Inventory; DSM-IV, Diagnostic and Statistical Manual, Fourth Edition; GADI, generalized anxiety disorder-7; HADS, Hospital Anxiety and Depression Scale; HAM-D, Hamilton Depression Rating Scale; MDD, major depressive disorder; PHQ-9, Patient Health Questionnaire, 9-Item Version; PBC, primary biliary cholangitis; PSC, primary sclerosing cholangitis; STAI, State-Trait Anxiety Inventory. While examining the effect of fatigue on quality of life in patients with primary biliary cholangitis, Huet and colleagues found self-reported DEP to be ~45%.24 Similarly, in a Dutch sample of 92 patients with either primary biliary cholangitis or PSC, self-reported DEP was found to be 42%, though only 3.7% of patients met DSM-IV criteria for MDD.26 While neither study measured symptoms of ANX, one recent investigation provided qualitative findings on PSC and ANX.29 Ranieri et al29 adopted a phenomenological approach to understand the subjective narratives of 22 patients with PSC who participated in 4 weeks of virtual focus groups. ANX was a frequent theme described by patients and often emerged at the time of PSC diagnosis. Further, ANX-based themes included the following concerns: risk of early mortality, reduced quality of life, worsening physical health, the need for further medical testing and/or transplant, and missed opportunities to celebrate developmental and lifetime achievements of their children.29 Several cross-sectional investigations assessed the prevalence of self-reported DEP and ANX in patients with AIH compared with age-matched and sex-matched controls.25,27,30 Schramm and colleagues reported that the frequency of self-reported DEP and moderate ANX among 103 German patients with AIH to be twice that observed in the German general population (ie, 5.9% vs. 2.6% DEP and 8.3% vs. 4.4% ANX). Further, 10.8% of patients with AIH met criteria for MDD and 4.2% presented with severe ANX, which were respectively, 5 and 4 times greater than rates in the general population (ie, 1.9% MDD and 1.1% ANX).27 The prevalence of DEP in patients with HBV has been examined,12,17,23,28,31,32 though limited data on rates of ANX are available.17,28 Comparative investigations commonly show that the prevalence of DEP in patients with HBV is lower than that in patients with HCV,12,17,32 a finding that extends to both self-report–diagnosed and clinician-diagnosed DEP. At least 1 investigation examined rates of self-reported DEP and ANX in patients with HBV.28 Yilmaz and colleagues showed that 60% of patients with HBV patients endorsed DEP compared with 47.2% of patients with inactive HBV and 25% of healthy controls. Similarly, 48.7% of patients with HBV endorsed ANX, followed by 33.5% and 20.7% of those with inactive HBV or healthy controls.28 SUMMARY DEP and ANX are prevalent in patients with LD. These associations persist even when considering multiple LD etiologies. Subsequently, DEP and ANX should not be underestimated in patients with LD, particularly since there is a growing body of evidence that both comorbidities can negatively impact patient-centered outcomes. Numerous well-validated, brief measures for assessing DEP and ANX in patients with LD are widely available, and both psychotropic medication management and/or psychological counseling are well-known treatments for these comorbidities. However, more targeted DEP and ANX treatment studies for patients with LD are needed at this time, particularly investigations that focus on the efficacy of affective symptom treatment within samples of patients diagnosed with varying LD etiologies.

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