FRI399 Prevalence Of Polycystic Ovary Syndrome In Women With Type 1 Diabetes In Pregnancy
Notice bibliographique
Résumé
Abstract Disclosure: S. Dolatabadi: None. J.M. Yamamoto: None. J.L. Benham: None. Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that is a risk factor for cardiometabolic disease such as impaired glucose tolerance, obesity, and hypertension. The prevalence of PCOS in the general population is estimated at 5-15% depending on the diagnostic criteria that is used. Although PCOS is commonly associated with type 2 diabetes (T2D), its association with type 1 diabetes (T1D) is less commonly investigated. The reported prevalence of PCOS in women with T1D is 24%. Furthermore, previous studies have found that women with either PCOS or T1D are at risk of preeclampsia, premature delivery, and neonatal complications such as congenital malformations and neonatal death. Unfortunately, there is a paucity of information regarding prevalence of PCOS in women with T1D in pregnancy as well as maternal and neonatal outcomes in this population. The objectives for this study were to 1) determine the prevalence of PCOS in pregnancies affected by T1D and 2) determine whether maternal and neonatal outcomes differed between women with T1D in pregnancy with or without a concomitant diagnosis of PCOS. A retrospective cohort study was performed of women affected by T1D in pregnancy that attended specialized Diabetes in Pregnancy clinics in Calgary, Alberta, Canada between 2008-2020. An individual was classified as having PCOS if there was a self-reported diagnosis of PCOS or if a patient met at least 2 of the 3 Rotterdam criteria based upon chart review. Logistic regression was planned to examine associations between maternal and neonatal outcomes. From 401 patients with T1D seen at Diabetes in Pregnancy Clinics, 14 (3.5%) patients had a self-reported diagnosis of PCOS. Given the low prevalence of PCOS in our patient population, the planned comparison of maternal and neonatal outcomes in patients with and without PCOS could not be completed. The prevalence of PCOS in women affected by T1D in pregnancy in this cohort was significantly lower than the reported prevalence of PCOS among women with T1D as well as the general population. Given that PCOS is associated with infertility and only women experiencing pregnancy were included in this study, exclusion of patients experiencing infertility could have affected the calculated prevalence. Overall, these results indicate that there is a lack of screening for PCOS in women affected by T1D during pregnancy. Given that both T1D and PCOS are associated with adverse maternal and neonatal outcomes, more education regarding this topic should be provided to healthcare professionals to ensure appropriate periconceptional and antepartum care of women with PCOS and pre-existing diabetes. Presentation: Friday, June 16, 2023
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».