P‐BB‐39 | Frequency of Vasovagal Reactions with Large‐Volume Plasma Donations in Canada
Notice bibliographique
Résumé
Vasovagal reactions (VVR) are reported as one of the most common adverse events with blood donation, and there is concern of increased VVR with large volume plasma collection. There is limited research from blood operators regarding the optimal combination of VVR mitigation strategies. Here we describe the observed rate of VVR at our new plasma collection sites between 2020 and 2022. Plasmapheresis donors can donate weekly with the maximum volume per donation decided based on the total estimated blood volume (TEBV) which is calculated based on measured height and weight. There is a stepwise process for increasing plasma volume collected, starting at 13% TEBV and progressing to a maximum of 18% TEBV. At every subsequent donation, donors were asked about experiencing vasovagal reactions prior to progressing to a higher TEBV threshold. Donors with over 562 mL of plasma volume collected were also given a 500 mL saline infusion. All donors are also advised to eat pre-donation, participate in directed applied muscle tension during procedure and consume at least 500 mL of water and eat a salty snack post-procedure while resting. Data regarding gender at registration, volume progression, VVR rate and severity were analyzed between January 01 2020 to December 31 2022. Between 2020 and 2022, 19,185 donors made 78,401 donations. The average age of donors was 43 years. Of these, 36,961 (47.1%) of donations were made by donors registered as female. At the end of 2022, 18.5% of the donors registered as female and 24.3% of donors registered as male had completed the volume progression and were at 18% TEBV donation level. The overall frequency of VVR amongst donors registered as male was 14 in 10,000 donations, while those registered as female was 37 in 10,000 donations. Moderate to severe VVR occurred at 199 (0.25%) donations. Of these, 86 (43.2%) VVRs were severe. Amongst the donors with VVR, 136 were registered as female with 31 at their first donation. Of the 63 reactions in donors registered as male, 37 were at their first donation. Of the VVR reported, 170 (85.4%) occurred during donation. Saline was administered in 52906 (67.4%) of donations with VVR reported in 32 of these donations, and the odds of having a VVR with saline of 0.0923 (95% confidence interval 0.063 to 0.135; p < .0001). Within the first 2 years of large volume plasma collections at dedicated sites and current mitigation strategies, the VVR rate has been reported in 0.25% of donations with a reduced odds ratio during the procedures where saline infusions are given.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,003 |
| Études des sciences et des technologies | 0,002 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».