S1479 Repeatability Coefficient of Velacur Scans in the Same Patient Taken at Least 2 Weeks Apart
Notice bibliographique
Résumé
Introduction: As non-invasive biomarkers become the standard of care for diagnosis and monitoring of patients with chronic liver disease, it is important to understand the repeatability of any test. Here we report the results of the ‘different-day’ measurements for Velacur elasticity and attenuation in patients with non-alcoholic fatty liver disease. Methods: As part of protocol for a clinical study, adult participants were asked to complete an additional optional visit with a repeated Velacur scan. All scans were completed by a qualified Velacur scanner, but the repeated scans were not always completed by the same scanner. Exams were collected at 2 sites, in Vancouver, BC and in Coronado, CA. Between 5 and 10 volume measurements were completed during each visit as per protocol and the median of these measurements was used as the exam result for this analysis. The primary objective was to estimate the repeatability coefficient (RPC) for both elasticity and attenuation measurements, on the same subject, on a different day. Scans were completed at least 2 weeks apart. Results: A total of 20 subjects with clinically confirmed non-alcoholic fatty liver disease were included in this analysis Velacur scan repeatability. The average number of days between scans was 24.8, ranging from 15 to 37 days. Average age for these patients was 57 years, and 52% were female. The mean BMI was 29.9 +/- 5.8 kg/m2, and mean FIB-4 was 1.72 +/- 1.05. The mean elasticity for visit 1 was 8.3 kPa and 8.1 kPa for visit 2. Patients represented the full spectrum of disease with stiffness with measurements for visit 1 ranging from 4.8 kPa to 15.2 kPa. The mean attenuation measurement for visit 1 was 324 dB/m and 313 dB/m for visit 2, ranging from 206 to 402 dB/m. The RCP for elasticity was 31% and for attenuation was 19%. Conclusion: The repeatability coefficients are important to be able to understand what a true change might constitute, rather than differences attributable to measurement error. The results measured here were taken further apart than during other similar studies (measured 7 days apart), so might also incorporate some real changes in the patient disease state. The results are the first step in understanding the repeatability of Velacur measurements in a NAFLD/NASH patient population (Figure 1).Figure 1.: Correlation and Bland-Altman plots of Velacur elasticity and attenuation for measurements taken from the same patient, at least 2 weeks apart.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,006 | 0,012 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».