Even Mealtime Distribution of Protein Intake Is Associated with Greater Muscle Strength, But Not with 3‐Year Decline, in Free‐Living Older Adults: The Nuage Study
Notice bibliographique
Résumé
Background Functional status declines with aging, impeding autonomy. Mealtime distribution of dietary protein was recently associated with muscle mass, yet its relation to physical performance remains unknown. Objective We examined the relationship between protein intake distribution and physical performance and its 3‐y decline, in community‐dwelling older adults. Design Three‐year follow‐up data from 827 men and 914 women (aged 67–84 y) participating in the longitudinal study on nutrition and successful aging (NuAge; Quebec, Canada) were analyzed. Physical performance, measured yearly, was grouped into 2 functional composite scores: muscle strength (handgrip, arm and leg) and mobility (timed up‐and‐go, chair stand, normal and fast walking speed). Dietary data were collected in 2 sets of 3×24‐h food recalls, at baseline and year 2. Individual mealtime protein distribution was calculated as the coefficient of variation (CV= SD/ χ̄) of grams of protein per meal. Mixed model analysis was used to examine trajectories of muscle strength and mobility across time, by sex, as conditioned by protein distribution, adjusted for age, protein quantity, education level, disease status, BMI, depression, cognitive function, smoking and mid‐upper arm muscle area. Results Physical performance deteriorated over 3 years, with muscle strength declining more than mobility score in men (−1.51±1.68 vs. −0.66±2.81) and women (−1.35±1.77 vs. −0.78±2.63), P <0.001. More evenly distributed protein intake, independently of total quantity, was cross‐sectionally associated with higher muscle strength score in men ( β ±SE; 0.44±0.18) and women (0.68±0.19), P <0.05 throughout follow‐up, before and after controlling for covariates. It was also associated with greater mobility score, only in men and before adjusting for covariates. Strength and mobility rates of decline were not affected by protein intake distribution in either sex. Also, higher protein quantity (g/d adjusted for energy) was independently associated with higher mobility score in both sexes and higher muscle strength in women (with a statistical trend in men) at each yearly follow‐up, but not with the longitudinal rate of decline over 3 years. Age was the only confounder affecting muscle strength decline over time. Conclusions In addition to the previously observed association with lean mass, an even distribution of daily protein intake across meals was independently associated with greater muscle strength, but not mobility score or functional decline, in older adults. Longer‐term investigation of the role of protein intake and its distribution, combined with other modifiable lifestyle factors, on physical performance is warranted. Support or Funding Information Dairy Farmers of Canada.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».