Consumption of Novel Thiamin‐Fortified Fish Sauce Improves the Thiamin Status of Rural Cambodian Women of Childbearing Age and Their Children <5 Years
Notice bibliographique
Résumé
Infantile beriberi, a disease caused by thiamin deficiency, remains a public health concern in Cambodia and other Southeast Asian countries that rely on thiamin‐poor white polished rice as a dietary staple. Infantile beriberi presents in exclusively breastfed infants of thiamin‐deficient mothers, and is often fatal if not treated within ~24 hours. Infantile beriberi has been nearly eradicated in regions where dietary diversity is high, or staple foods are fortified with thiamin. Food fortification is an inexpensive, sustainable, and passive means of improving the diet when micronutrients are lacking. We formulated a novel thiamin‐fortified fish sauce (a traditional condiment consumed daily by rural Cambodians) to determine whether ad libitum consumption over six months could improve erythrocyte thiamin diphosphate concentrations (TDP) among women of childbearing age and their youngest child aged 12–59 m, compared to a control sauce. In this double‐blind, randomized controlled efficacy trial 276 non‐pregnant, non‐lactating women aged 18–45 y and their families in Prey Veng, Cambodia, were randomized to receive one of three fish sauce formulations: low concentration thiamin (LC; ~2g/L), higher concentration thiamin (HC; ~8g/L), or control (C; no thiamin). TDP was analyzed using HPLC‐FLD. Women were 30 ± 6 y, and 71% of women had a normal BMI (18.5–25 kg/m 2 ). Children were 30 ± 15 m at baseline. Women's baseline mean (95% CI) TDP for HC ( n =91), LC ( n =93), and C ( n =92) was 179 nM (167, 191), 172 nM (162, 183), and 150 nM (142, 158), respectively. Children's baseline mean (95% CI) TDP for HC ( n =87), LC ( n =88), and C ( n =87) was 211 nM (197, 225), 194 nM (183, 206), and 172 nM (163, 181), respectively. Fish sauce consumption was not significantly different between groups (p=0.186). In intent‐to‐treat analysis, women's endline TDP (adjusted for baseline) significantly increased among women in HC (53 nM) and LC (49 nM) groups compared to C (p<0.001). Similarly, at endline children's (baseline adjusted) TDP was 47 nM and 36 nM higher in the HC and LC groups, respectively, compared to C (p<0.001). Consumption of thiamin‐fortified fish sauce at concentrations of 2g/L and 8g/L over six months significantly improved biochemical thiamin status of Cambodian women of childbearing age and young children under 5 years. Effectiveness trials, as well as further research to identify the optimal dose for thiamin fortification, are needed. Support or Funding Information Research supported by Grand Challenges Canada Stars in Global Health Grant (Round VI), Canadian Institutes of Health Research (CIHR) Doctoral Award, and International Development Research Centre (IDRC) Doctoral Research Award.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».