S3 Communicating Needs and Features of IBD Experiences (CONFIDE) Survey: United States and European Patient Perspectives on the Impact of Moderate to Severe Crohn’s Disease on Sexual Activity
Notice bibliographique
Résumé
Background: Crohn’s Disease (CD) symptoms impact several aspects of quality of life (QoL), including sexual health. Patients with CD may be embarrassed to discuss sexual health, and health care professionals (HCPs) may fail to query the issue with patients. In previous analyses from the Communicating Needs and Features of IBD Experiences (CONFIDE) study, most patients with moderate to severe ulcerative colitis (UC) reported avoiding or decreasing sexual activity due to UC, with bowel urgency (BU) and BU-related accidents being among the most common reasons. Data from the CONFIDE study were used to explore the impact of CD symptoms on sexual activity. Methods: Online, quantitative, cross-sectional surveys exploring the experiences and impacts of symptoms on patients with CD or UC were conducted in the US, Europe (France, Germany, Italy, Spain, and UK), and Japan. Data presented here are from the US and Europe. Moderate-to-severe CD was defined using criteria based on previous treatment, steroid use, and/or hospitalization. Patients were asked whether they avoided or decreased sexual activity due to CD; if yes, the underlying reasons were explored. To include all patients regardless of their partner status, sexual activity was not limited to intercourse and included activities such as masturbation. The analyses were descriptive in nature. Results: Overall, 215 US (male [M]=54.9%, mean age 40.9 years) and 547 European patients (M=55.4%, mean age 38.0 years) completed the survey. In addition, 58.1% US and 63.4% European patients were receiving advanced therapies (biologic/novel oral), and 23.7% US and 16.1% European patients experienced fistula-related symptoms around the anus/rectum. Overall, 68.8% US (M=69.5%, female [F]=68%) and 55.8% European patients (M=55.1%, F=56.6%) reported avoiding or decreasing sexual activity due to CD in past 3 months. Among these, the top three reasons for avoidance of sexual activity were fear of BU-related accidents (41.2%), fear of fecal seepage (39.2%), and abdominal pain (38.5%) in US and fear of BU-related accidents (30.5%), BU itself (29.8%), fatigue (29.5%), and abdominal pain (29.5%) in Europe. In the US, greater proportion of male patients reported fear of BU-related accidents (M=46.3%, F=34.8%), fear of fecal seepage (M=41.5%, F=36.4%), fatigue (M=40.2%, F=34.8%), BU (M=31.7%, F=22.7%), feeling physically unattractive (M=25.6%, F=19.7%), pain in genital area during sexual activity (M=23.2%, F=18.2%), self-conscious about not feeling clean (M=19.5%, F=12.1%), and difficulty reaching orgasm (M=13.4%, F=7.6%). In Europe, greater proportion of male patients reported fear of BU-related accidents (M=34.1%, F=26.1%), increased stool frequency (M=31.7%, F=18.8%), blood in stool (M=29.9%, F=8.7%), and perianal pain (M=28.7%, F=15.9%). However, greater proportion of female patients reported worsening of abdominal pain during intercourse (M=24.4%, F=30.3%) in the US and reduced sexual desire (M=24.6%, F=29.7%), feeling physically unattractive (M=15.6%, F=29.7%), and self-conscious about not feeling clean (M=16.8%, F=22.5%) in Europe. Conclusions: Similar to patients with UC, in US and Europe, most patients with moderate to severe CD reported avoiding or decreasing sexual activity. Fear of BU-related accidents was the top reason for avoidance of sexual activity in the US and Europe. Sexual well-being is an important aspect of overall QoL and needs to be addressed for patients with CD in routine clinical practice.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,006 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,002 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».