Analysis the relationship of cholinergic pathway damage and cerebral cortex structure change in patients with cognitive impairment accompanied by white matter hypertensity
Notice bibliographique
Résumé
Objective To investigate the relationship of cholinergic pathway (CP) damage and cerebral cortex structure change in patients with different degree of cognitive impairment accompanied by white matter hyperintensity (WMH). Methods From March 2016 to December 2018, a total of 80 patients with WMH were rolled into WMH with no cognitive impairment group (WMH⁃CN group, n = 43), WMH with vascular cognitive impairment⁃no dementia group (WMH⁃VCIND group, n = 21) and WMH with vascular dementia group (WMH ⁃ VaD group, n = 16), according to Montreal Cognitive Assessment (MoCA) and Clinical Dementia Rating Scale (CDR). White matter damage in CP were evaluated by Cholinergic Pathways Hyperintensities Scale (CHIPS). MRI was performed on all patients, 34 regions of interest (ROIs) in cerebral cortex CP were marked, and layer thickness and volume were measured. Spearman rank correlation analysis and partial correlation analysis were performed to explore the correlation between the total CHIPS score of left and right hemispheres and ipsilateral cortical ROIs thickness and volume. Results 1) The CHIPS scores of WMH ⁃ CN group, WMH ⁃ VCIND group and WMH ⁃ VaD group had statistically significant differences in the whole brain (P = 0.023), the left hemisphere (P = 0.039) and the right hemisphere (P = 0.004), respectively. Among them, the CHIPS scores of WMH⁃VCIND group (P = 0.002, 0.000, 0.001) and WMH⁃VaD group (P = 0.000, 0.003, 0.000) were all higher than those of WMH⁃CN group. The CHIPS scores of three regions in WMH⁃VaD group were also higher than those in WMH⁃VCIND group (P = 0.008, 0.013, 0.020). 2) The differences of the left hemisphere ROIs layer thickness (P =0.000) and volume (P = 0.000), and the right hemisphere ROIs layer thickness (P = 0.000) were statistically significant between WMH patients and normal controls. The left hemisphere ROIs layer thickness (P =0.000, for all) and volume (P = 0.000, for all), and the right hemisphere ROIs layer thickness (P = 0.000, for all) in WMH⁃CN group, WMH⁃VCIND group and WMH⁃VaD group were all lower than those in control group. In WMH⁃VaD group, the thickness of left ROIs was higher than that of WMH⁃CN group (P = 0.000) and WMH⁃VCIND group (P = 0.036). In WMH⁃CN group, the volume of left ROIs was higher than that in WMH⁃VCIND group (P = 0.033) and lower than that in WMH⁃VaD group (P = 0.025), and the thickness of right ROIs in WMH⁃VCIND group (P = 0.001) and WMH⁃VaD group (P = 0.000) were both higher than that in WMH ⁃ CN group. 3) Correlation analysis showed that only the WMH ⁃ VCIND group had a positive correlation between left hemispheric CHIPS score and ipsilateral cortical ROIs (r = 0.439, P = 0.047). Conclusions When WMH patients with cognitive impairment, as the degree is aggravating, the thickness and volume of 34 ROIs on left hemisphere CP have a certain degree of decline. The cerebral cortex structure change was positively associated with the degree of left hemisphere CP damage, but the structural change is not obvious in right hemisphere. DOI:10.3969/j.issn.1672⁃6731.2020.10.009
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».