Low Dose Corticosteroids in Management of Hyperemesis Gravidarum at Mansoura University Hospital
Notice bibliographique
Résumé
Objective: to show the effect of addition of corticosteroids to standard treatment of hyperemesis gravidarum with respect to initial response of treatment, reduction of severity of vomiting , improvement of quality of life and rate of readmission to hospital . Design: RCT (Canadian Task Force Classification- I). Setting: Mansoura University HospitalsPatients: Fifty pregnant women suffering from hyperemesis gravidarum were admitted to department of obstetrics and gynecology, Mansoura University Hospitals. Interventions: Patients were randomized into two groups; group 1 (Corticosteroid group; n = 25) and group 2 (non-corticosteroid group; n = 25) at 1:1 ratio.Measurements and Main Results: The primary outcome was the severity of vomiting after 48 hours after start of the treatment using Pregnancy-Unique Quantification of Emesis (PUQE) score. The secondary outcomes were quality of life after 48 hours and 1 week from starting the treatment protocol using a rating scale with a range between zero (the worst possibly imaginable) and ten (equaled as good as she felt before the start of this pregnancy) , assessment of severity of vomiting after 1 week of start of the treatment using PUQE score , rate of readmission to the hospital within 2 weeks of treatment , extent of ketonuria , and length of hospital stay. The severity of vomiting after 48 hours of start of the treatment using PUQE score decreased significantly in the corticosteroid group, being 10.64 ± 1.62 compared to 11.88 ± 1.64 in the control group. PUQE score after 1 week of start of the treatment was comparable again between the two studied groups. The quality of life (QOL) of patients after 48 hours from starting the treatment score was statistically higher among the corticosteroid group being 5.8 ± 0.8 compared to 4.6 ±1.2 in the control group p value ≤0.05 which continued after 1 week being higher among the corticosteroid group, 8.3 ±0.9 compared to 7.6 ± 0.7 in the control group. The rate of readmission to the hospital for hyperemesis gravidarum within 2 weeks of starting the study was higher among the control group being 32% versus only 4% in the group taking corticosteroids. Also, the median length of stay was higher among the control group, 7 days ranged from 4 to 28 days compared to 4 days ranged from 3 to 12 days in the corticosteroid group. Conclusions: Corticosteroids were highly effective in reducing the severity of vomiting in HG patients after 48 hours from the start of the treatment using PUQE score and improving their QOL score compared with the standard treatment in the control group.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».