Genetic predisposition of LEPR (rs1137101) gene polymorphism related to type 2 diabetes mellitus – a meta-analysis
Notice bibliographique
Résumé
Background: type 2 diabetes mellitus (t2DM) is a multifaceted disease appropriate to elevated blood glucose levels resulting from decreased insulin and beta-cell activity.Using a case-control methodology, researchers have examined the relationship between polymorphisms in lePR and t2DM in a population from south india.Materials and Methods: We conducted a genetic analysis of 311 participants, and results were accomplished using a case-control study, a meta-analysis of previous studies on lePR was conducted, and type 2 diabetes genotype distribution across various geographical regions Malaysians, chinese han, Kuwait, iran, Mongolia, and han chinese, Greece, saudi, india (North india, Punjabi), (south india, tamilnadu).the study involved 254 prospective investigations, and nine association studies were preferred according to preset criteria.studies were assessed for quality using the hardy-Weinberg equilibrium (hWe) and the Newcastle-Ottawa scale (NOs).an analysis of the genetic models was conducted to determine their relationship, statistical analysis was utilized to calculate odds ratios (ORs) and matching 95% confidence intervals (cis).Results: the LEPR-rs1137101 polymorphism in the case-control study was associated with a significant increase in the risk of type 2 diabetes.a meta-analysis revealed a connection between LEPR gene polymorphism (rs1137101) and type 2 diabetes risk.investigators might gain a more profound thought on the significance of the identified genetic variation and its impact on the chance of developing type 2 diabetes by verifying and strengthening previously reported findings.the model of fixed effects was chosen due to the low heterogeneity, and significant associations were observed in the allelic (OR = 0.79, 95% ci [0.70-0.87]),homozygote (OR = 0.58, 95% ci [0.46-0.72]),dominant (OR = 0.66, 95% ci [0.56-0.79]),and recessive (OR = 0.83, 95% ci [0.71-0.96])genetic models.a Begg's funnel plot and egger's test indicated no publication bias.these findings suggest that the rs1137101 variant in the LEPR gene has been linked to a higher risk of t2DM.Conclusions: a larger sample size, however, is required for further research, and consideration of potential confounding factors is needed to validate these associations.Understanding the implications of LEPR gene polymorphisms in t2DM susceptibility may contribute to personalized treatment strategies for patients with t2DM. KEY MESSAGES t2DM is the prevailing diabetes type globally, impacting approximately 90% of people living with diabetes.t2DM has become more commonplace, irrespective of socioeconomic status or demographic background. t2DM is characterized by hyperglycemia caused by increased blood glucose levels.Recent research indicates a substantial global rise in t2DM cases, suggesting a growing public health concern. the development of type 2 diabetes is influenced by both environmental and genetic factors.among the genetic factors, the LEPR gene (leptin receptor gene) has been extensively studied and is associated with insulin sensitivity, hunger regulation, and energy consumption.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,003 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
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