Global study reveals almost half of patients with skin disease suffer from sleep disturbances and identifies predictive factors
Notice bibliographique
Résumé
Sleep is a physiological process that accounts for almost one third of a person's life.1 Sleep disturbances (SDs) are distressing and disabling conditions that are frequently reported in cutaneous disorders (CD) with significant impairment in quality of life. However, predictive factors of SD in patients with CD has poorly been investigated.2-4 Our objective was to conduct a worldwide study in order to evaluate the prevalence of SD due to CD and identify predictive factors and impact on professional life. The 'ALL PROJECT'5 involves individuals, representative of the adult populations of 20 countries spread over all five continents [China 5000, USA 5000, Brazil 4001, India 3000, Australia 2000, France 4000, Italy 4000, Canada 2500; Denmark 1000; Germany 2000; Israel 2000; Kenya 500; Mexico 2500; Poland 2500; Portugal 1000; Senegal300; South Africa 1000; South Korea 2500; Spain 2000; UAE 750], which together accounts for over 50% of the world's population. In each of the 20 countries surveyed we conducted a population-based study on representative and extrapolable samples of the general population aged 16 years or more. The questionnaire gathered information about the patients' demographic and socio-demographic profiles. Patients were considered to have SD if they reported that they had difficulty in failing asleep because of their CD. A comparison of SD and patients without SD (non-SD) was used to evaluate predictors of SD: socio-demographic and clinical parameters and specifically on professional life. A total of 50,552 individuals participated in the survey, of which 17,627 (Tables 1 and 2) had CD. There were 7514 (42.6%) males and 10,113 (57.4%) females, respectively (mean age 39.65 ± 14.97. 16–96 years). A total of 7458 (42.3%) respondents reported SD due to a CD. The SD population was, on average younger than the non-SD population (mean age 39.22 ± 14.38 years vs. 39.96 ± 15.38 years; p = 0.001). Females had more frequently SD than males (40.8% vs 43.5%. p = 0.01). 10,169 (57.7%)respondents were considered to have no SD. Symptoms such as prickles, burning sensations, tingling (16.5% vs 14.2%, p 0.001388) skin pain (6.6% vs 3.6%1.4E-16) and pruritus (60.5% vs 50.8%, p < 0.0001) were predictive factors of SD. Subjects with SD reported more frequently a feeling of fatigue as soon in the waking up (80.70% vs 63.60%, p < 0.0001) a decrease in concentration and vigilance (73.40% vs 55.10%, p < 0.0001), periods of drowsiness during the day (82.60% vs 71.00%, p < 0.0001), a tingling sensation in the eyes (58.10% vs 42.20%, p: <0.0001) and repeated yawning (71.70% vs 57.90%, p < 0.0001). SD was significantly associated with detrimental impact on work life with feeling less productive in the activity (49.2% vs 19.4%, <0.0001). This is the first study to establish the impact of SD, which affects 42.3% % of respondents with CD. While CD that cause SD may be transient, long-term or recurrent, they all lead to significant psychological complications. We reported that SD in patients with CD was significantly associated with feeling of fatigue, decrease in concentration and vigilance, drowsiness, tingling sensation in the eyes and repeated yawning. These findings suggest the importance of early detection and management of SD in patients with CD which may contribute to detrimental impact on professional life. It is important to include questions about SD in the examinations of CD patients.2, 3, 6-9 SD must be regularly assessed and managed and guidelines are needed to address the multifactorial nature of SD in patients with CD. The authors acknowledge the technical support of Helene Chevalier (HC Conseil). This project was funded by Patient Centricity of Pierre Fabre. Catherine Baissac, Nuria Perez Cullell, Marketa Saint Aroman are employees of Pierre Fabre, France. Dr Charbel Skayem, Charles Taieb, Yaron Ben Hayon, Briuno Halioua, Marie Aleth Richard, Jonathan Taieb have no conflict of interests. The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».