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Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Joshua A Welsh, Deborah C. I. Goberdhan, Lorraine O’Driscoll, Edit I. Buzás, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Juan Manuel Falcón‐Pérez, Qing‐Ling Fu, Andrew F. Hill, Metka Lenassi, Sai Kiang Lim, Mỹ G. Mahoney, Sujata Mohanty, Andreas Möller, Rienk Nieuwland, Takahiro Ochiya, Susmita Sahoo, Ana Cláudia Torrecilhas, Lei Zheng, Andries Zijlstra, Sarah Abuelreich, Reem Bagabas, Paolo Bergese, Esther Bridges, Marco Brucale, Dylan Burger, Randy P. Carney, Emanuele Cocucci, Rossella Crescitelli, Edveena Hanser, Adrian L. Harris, Norman J. Haughey, An Hendrix, Tijana Jovanović‐Talisman, Nicole A. Kruh‐Garcia, Diego Kyburz, Cecilia Lässer, Kathleen M. Lennon, Jan Lötvall, Adam L. Maddox, Elena S. Martens‐Uzunova, Rachel R. Mizenko, Lauren A. Newman, Andrea Ridolfi, Eva Rohde, Tatu Rojalin, Andrew Rowland, András Saftics, Ursula S. Sandau, Julie A. Saugstad, Faezeh Shekari, Simon Swift, Dmitry Ter‐Ovanesyan, Juan Pablo Tosar, Zivile Useckaite, Francesco Valle, Zoltán Varga, Edwin van der Pol, Martijn J. C. van Herwijnen, Marca H. M. Wauben, Ann M. Wehman, S Williams, Andrea Zendrini, Alan Zimmerman, Clotilde Théry, Kenneth W. Witwer
Notice bibliographique
RevueJournal of Extracellular Vesicles · 2024
Typearticle
Langueen
DomaineBiochemistry, Genetics and Molecular Biology
ThématiqueExtracellular vesicles in disease
Établissements canadiensCelerion (Canada)University of Ottawa
Organismes subventionnairesNHLBI Division of Intramural ResearchJonsson Comprehensive Cancer CenterNational Center for Advancing Translational SciencesNIH Clinical CenterNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of General Medical SciencesNational Institute on Drug AbuseNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Institute on AgingFaculdade de Ciências da Saúde, Universidade de MacauSchool of Science, Monash University MalaysiaNano Institute, University of SydneyServicio Gallego de SaludInstituto de Tecnologia Química e Biológica, Universidade Nova de LisboaInstituto de Higiene e Medicina Tropical, Universidade Nova de LisboaHelmholtz Zentrum MünchenTongji Medical College, Huazhong University of Science and TechnologyLaboratório Nacional de BiociênciasForestry and Agricultural Biotechnology Institute, University of PretoriaFaculty of Medicine, Memorial University of NewfoundlandNational Institute of Dental and Craniofacial ResearchFaculty of Medical Sciences, Newcastle UniversitySchool of Medicine, Shanghai Jiao Tong UniversityUniversité de NamurInstitute of Molecular and Cell BiologyCollege of Medicine, Korea UniversityDet Sundhedsvidenskabelige Fakultet, Københavns UniversitetDepartment of Biochemistry, University of CambridgeSahlgrenska AkademinSchool of Medicine, University of North Carolina at Chapel HillBarts and The London School of Medicine and DentistryWageningen University and ResearchEngineering and Physical Sciences Research CouncilMedical Research CouncilCenter for Health Sciences, Oklahoma State UniversityLaureate Institute for Brain Research, University of TulsaHealth Canadalékařská fakulta Univerzity KarlovyCollege of Medicine, Seoul National UniversityNYU Grossman School of MedicineRoyal Veterinary CollegeFaculté de Médecine, Université LavalCollege of Medicine, University of CincinnatiAnschutz Medical Campus, University of ColoradoIrving Medical Center, Columbia UniversityChildren's Hospital Research Institute of ManitobaCollege of Dental Medicine, Columbia UniversityResearch Institute, Nationwide Children's HospitalAudrey and Theodor Geisel School of Medicine at DartmouthCollege of Science and Engineering, University of MinnesotaGraduate School of Public Health, University of PittsburghBiotechnology and Biological Sciences Research CouncilUniversity of North Carolina at Chapel HillWeill Cornell Medical CollegeAcademic Center for Education, Culture and ResearchCollege of Engineering, Michigan State UniversityImperial College LondonSchool of Medicine, New York UniversityUniversity of Illinois at Urbana-ChampaignBrain Tumour ResearchTsinghua UniversityUniversidad de la República UruguayInstitut National de la Santé et de la Recherche MédicaleRenji HospitalHumanitas Research HospitalYeditepe ÜniversitesiUniversiteit LeidenUniversity of SussexHomi Bhabha National InstituteUniversité Grenoble AlpesIstituto Superiore di SanitàHubei UniversityPennsylvania State UniversityUniversité de Franche-ComtéInstituto Nacional de Medicina GenómicaParacelsus Medizinische PrivatuniversitätUniversité de LiègeUniversitat Autònoma de BarcelonaHubei University of Science and TechnologySouthern Medical UniversityEötvös Loránd TudományegyetemUniversiteit HasseltScience for Life LaboratoryUniversitätsklinikum ErlangenTaipei Medical University HospitalUniversitat de les Illes BalearsInselspital, Universitätsspital BernXiamen UniversityVšeobecná Fakultní Nemocnice v PrazeUniversität Duisburg-EssenEesti MaaülikoolKU-KIST Graduate School of Converging Science and TechnologyÅbo AkademiSveriges LantbruksuniversitetUniversität zu KölnHögskolan i SkövdeTokyo Medical and Dental UniversityTartu ÜlikoolUniversiteit van AmsterdamIstituto Ortopedico Rizzoli di BolognaLigue Contre le CancerSorbonne UniversitéUniverza v LjubljaniNingbo UniversityUniversidad de Buenos AiresUniversità di PisaUniversità degli Studi di BresciaAllgemeine UnfallversicherungsanstaltJikei University School of MedicineUppsala UniversitetUniversidade do PortoAmsterdam University Medical CentersFundação Oswaldo CruzBar-Ilan UniversityNational Taiwan UniversitySyddansk UniversitetComprehensive Cancer Center at Wake Forest Baptist Medical CenterAalborg UniversitetshospitalUniversidade Nova de LisboaUniversity of South CarolinaNational Institute of Science Education and ResearchUniversidad de ChileDeakin UniversityUniversitat de BarcelonaGöteborgs UniversitetCentre Léon BérardUniversidade de CoimbraUniversidade de São PauloMemorial University of NewfoundlandHáskóli ÍslandsUniversitetet i OsloAdvanced Materials and Bioengineering ResearchInstytut Biologii Doswiadczalnej im. M. Nenckiego PANNational Institute of Biomedical Imaging and BioengineeringUniversity of St AndrewsUniversità di BolognaUniversité de MontréalRigshospitaletVersus ArthritisUniversitair Medisch Centrum GroningenNantong UniversityHospices Civils de LyonSchool of Medicine, Emory UniversityUniversity of TulsaJohannes Gutenberg-Universität MainzKeele UniversityLeids Universitair Medisch CentrumUniversiteit MaastrichtUniversitetet i BergenNational Tsing Hua UniversityCentre Hospitalier Universitaire de QuébecUniversité de Recherche Paris Sciences et LettresCHA UniversityChinese University of Hong KongAston UniversityCentre National de la Recherche ScientifiqueAstraZenecaUniversità degli Studi di ParmaUniversity of TokyoUniversité de ToulouseUniversidad de MurciaLondon Metropolitan UniversityUniversity of LeedsTechnische Universität MünchenUniversité de BourgogneUniversidad Autónoma de MadridUniversity of PennsylvaniaMinistry of Education, IndiaMasarykova UniverzitaNational Eye InstituteNanfang HospitalUniversität ZürichMaastricht Universitair Medisch CentrumShenzhen Research Institute, City University of Hong KongUniversiteit GentRijksuniversiteit GroningenTaipei Medical UniversityTel Aviv UniversityHospital for Sick ChildrenUniversidade Federal do ParáSapienza Università di RomaKungliga Tekniska HögskolanShaoyang UniversityVrije Universiteit AmsterdamUniversité de FribourgKarolinska InstitutetUniversité de LausanneInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'EnvironnementKU LeuvenJinan UniversityNottingham Trent UniversityTurun YliopistoIrish Cancer SocietyUniversità degli Studi di TrentoChristine Kühne – Center for Allergy Research and EducationAustralian National UniversityIkerbasque, Basque Foundation for ScienceUniversité de BordeauxDirectorate for Biological SciencesUniversità degli Studi di TorinoUniversité de StrasbourgWake Forest School of MedicineInstitució Catalana de Recerca i Estudis AvançatsKorea Institute of Science and TechnologyNovo Nordisk Foundation Center for Basic Metabolic ResearchUniversitat Politècnica de ValènciaUniversitetet i TromsøUniversité Paris-SaclayHuazhong University of Science and TechnologyQueen's UniversityUniversität WienErasmus Medisch CentrumTechnische Universiteit EindhovenUniversité de MontpellierUniversitätsklinikum KölnUniversity of QueenslandConsejo Nacional de Investigaciones Científicas y TécnicasChalmers Tekniska HögskolaCentral Queensland UniversityKorea UniversityHarvard UniversityCancer Research WalesNewcastle UniversityKonkuk UniversitySeoul National UniversityOklahoma State UniversityGachon UniversityYonsei UniversityTechnische Universität DresdenInstitut for Klinisk Medicin, Aarhus UniversitetPohang University of Science and TechnologyKyungpook National UniversityUniversiti Kebangsaan MalaysiaSchool of Medicine, University of MissouriTongji UniversityUniversity College LondonSemmelweis EgyetemCentro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y NanomedicinaWarszawski Uniwersytet MedycznyAgResearchAcademia SinicaErasmus Universiteit RotterdamVeterinärmedizinische Universität WienMike and Josie Harper Cancer Research InstituteChulalongkorn UniversityUniversidad de Costa RicaInstituto de Salud Carlos IIINationwide Children's HospitalQueensland University of TechnologyCurtin University of TechnologyHackensack Meridian HealthUniversity of South AustraliaVictoria UniversityUniversity of MelbourneMonash UniversityUniversity of HertfordshireCenter for Alcohol StudiesYork UniversityUniversity of Technology SydneyUniversity of SydneySchool of Medicine, Vanderbilt UniversityInstitut Pasteur de MontevideoFlorida Department of HealthWeizmann Institute of ScienceUniversité de LyonUniversity of California, San DiegoAalborg UniversitetHokkaido UniversityUniwersytet WarszawskiKlinisk Institut, Aalborg UniversitetKeio UniversityUniversité LavalSzegedi TudományegyetemSun Yat-sen UniversityUniversity of AucklandAgency for Science, Technology and ResearchUniversidade Estadual de CampinasUniversità degli Studi di Napoli Federico IIBeijing Advanced Innovation Center for Structural Biology, Tsinghua UniversityCentro de Biología Molecular Severo OchoaLa Trobe UniversityQueen Mary University of LondonQueen's University BelfastCardiff UniversityUniversity of MinnesotaIonis PharmaceuticalsNovo NordiskUniversity of OxfordEtablissement Français du SangDartmouth CollegeYonsei University College of MedicineUniversity of WestminsterGentofte HospitalUniversity of TorontoSaban Research InstituteUniversity of North TexasAberystwyth UniversityConsiglio Nazionale delle RicercheCarnegie Mellon UniversityNational Institute for Health and Care ResearchMedizinische Universität WienUniversité Catholique de LouvainTrent UniversityNankai UniversityFourth Military Medical UniversityEdward Via College of Osteopathic MedicineUniversity of SurreyUniversity of California, DavisSanjay Gandhi Postgraduate Institute of Medical SciencesShanghai Jiao Tong UniversityKasturba Medical College, ManipalUniversidade de MacauElettra-Sincrotrone TriesteSteno Diabetes Center CopenhagenSheffield Hallam UniversitySzkola Glówna Gospodarstwa Wiejskiego w WarszawieUniversidade de LisboaKanazawa UniversityNational Institute of Allergy and Infectious DiseasesUniversity of California, San FranciscoAgence Nationale de la RechercheUniversity of SheffieldUniversitat de LleidaSysmex CorporationNazarbayev UniversitySomerville College, University of OxfordCollege of Veterinary Medicine, Kansas State UniversityMansoura UniversityChildren's National HospitalNational Center for Geriatrics and GerontologyVanderbilt University Medical CenterUniversity of HyderabadNational Institute of Child Health and Human DevelopmentUniversitätsklinikum Hamburg-EppendorfUniversité de LilleColorado State UniversityUniversity of PretoriaEastern Virginia Medical SchoolConcordia UniversityWellesley CollegeMacquarie UniversityTouro University CaliforniaOncode InstituteDalhousie UniversityCedars-Sinai Medical CenterRheinische Friedrich-Wilhelms-Universität BonnUniversity of Southern CaliforniaSylvester Comprehensive Cancer Center, University of Miami Health SystemsUniversité de ParisUniversität UlmMeso Scale DiagnosticsChina National Biotec Group CompanyUniversitair Medisch Centrum UtrechtUlsan National Institute of Science and TechnologyPázmány Péter Katolikus EgyetemRoyal College of Surgeons in IrelandPolitecnico di TorinoMassachusetts General HospitalChildren's Healthcare of AtlantaUniversity of MissouriSwansea UniversityNew Zealand Institute for Plant and Food Research LimitedFlorida State UniversityPeking UniversityMedical Center, University of PittsburghClínica Las CondesUniversity of Texas MD Anderson Cancer CenterNational Institutes of HealthNational University of SingaporeRadboud Universitair Medisch CentrumU.S. Department of Veterans AffairsOxford Brookes UniversityCleveland ClinicUniversity of South AlabamaFundació Institut de Recerca Hospital Universitari Vall d’HebronMasonic Cancer Center, University of MinnesotaUniversidad Europea de MadridHarvard T.H. Chan School of Public HealthGeorgetown UniversityUniversity of MiamiCentro Nacional de Pesquisa em Energia e MateriaisUniversity of Central LancashireBudapesti Műszaki és Gazdaságtudományi EgyetemConsejo Superior de Investigaciones CientíficasSanta Clara UniversityUniversità Degli Studi di Modena e Reggio EmilaLoughborough UniversityUniversitat Ramon LlullQIMR Berghofer Medical Research InstituteNational Cancer InstituteCenter for Clinical and Translational ResearchWake Forest UniversityBritish Heart FoundationUniversity of PittsburghEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentUniversity of BernKorea Advanced Institute of Science and TechnologyCanadian Institute for Theoretical AstrophysicsHansjörg Wyss Institute for Biologically Inspired Engineering, Harvard UniversityUniversità degli Studi di Roma Tor VergataSichuan UniversityLeibniz-GemeinschaftUniversity of OttawaThomas Jefferson UniversityUniversità degli Studi di PerugiaUniversität BaselUniverzita Karlova v PrazeMcGill UniversityUniversidade Federal do Rio de JaneiroNational Institute for Genetic Engineering and BiotechnologyUniversité de LorraineBeckman Research Institute, City of HopeSidney Kimmel Comprehensive Cancer CenterShandong UniversityBayerUniversity of OtagoUniversità degli Studi di PadovaUniversity of Notre DameMonash University MalaysiaChapman UniversityUniversity of GalwayComprehensive Cancer Center, City of HopeUniversiteit AntwerpenOhio State UniversityJohns Hopkins UniversitySungkyunkwan UniversityBrigham and Women's HospitalFriedrich-Alexander-Universität Erlangen-NürnbergVlaamse Instelling voor Technologisch OnderzoekTulane UniversityUniversity of California, Los AngelesUniversity of DenverInstitute for Basic ScienceUniversitat de ValènciaUniversity of Nebraska-LincolnHouston Methodist Research InstituteVanderbilt UniversityUniversity of CincinnatiChung Shan Medical UniversityCancer Center AmsterdamHelsingin YliopistoMichigan State UniversityWallenberg Centre for Molecular and Translational MedicineRoyan InstituteDeutsches KrebsforschungszentrumIstituto Pasteur-Fondazione Cenci BolognettiDivision of Intramural Research, National Institute of Allergy and Infectious DiseasesNational Institute of Neurological Disorders and StrokeNational Center of Neurology and PsychiatryAarhus UniversitetAix-Marseille UniversitéDebreceni EgyetemUniversity of Florida HealthGuangzhou Medical UniversityGeorge Mason UniversityFakultet Medicinskih Nauka, Univerziteta U KragujevcuUniversity of UtahChildren's Hospital Los AngelesSouth Asian UniversityCancer Research InstituteDaegu Gyeongbuk Institute of Science and TechnologyUniversity of California, IrvineUniversity of Texas Medical BranchEvercyteUniversità degli Studi di PalermoGeorge Washington UniversityRadboud UniversiteitUniversiteit UtrechtFlinders UniversityAlbert-Ludwigs-Universität FreiburgInstitut Gustave-RoussyInstitut d'Investigació Sanitària Pere VirgiliTrinity College DublinMcGill University Health CentreInstitut de Cardiologie de MontréalNorthwestern UniversityFaculty of Health and Medical Sciences, University of Western AustraliaItä-Suomen YliopistoUniversity of AdelaideBrandeis UniversityUniversity of Nebraska Medical CenterUniversity College DublinAkademie Věd České RepublikyKorea University Guro HospitalYale UniversityEmory University
Mots-clésExtracellular vesiclesExtracellular vesicleComputer scienceNanotechnologySnapshot (computer storage)Synthetic biologyComputational biologyVesicleData scienceBiochemical engineeringMicrovesiclesBiologyCell biologyEngineeringMaterials scienceBiochemistry
Résumé
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
score de la tête « metaresearch » (Codex)0,003
score de la tête « metaresearch » (Gemma)0,006
Version: metacan-v3-hybrid-931329e0061cStatut de validation: machine_predicted_unvalidated
Catégories candidatesMétarecherche
Catégories consensuellesaucune
DomaineSignal candidat: Présentation des résultats · Signal consensuel: aucune
Devis d'étudeSignal candidat: Sans objet · Signal consensuel: aucune
GenreSignal candidat: Méthodes · Signal consensuel: Méthodes
Score de désaccord entre enseignants0,997
Score d'incertitude au seuil0,054
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,006 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,002 | 0,003 |
| Science ouverte | 0,001 | 0,003 |
| Intégrité de la recherche | 0,002 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,016 | 0,011 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
Tête enseignante Opus0,036
Tête enseignante GPT0,287
Écart entre enseignants0,251 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validation
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Devis d'étudeSans objet
DomainePrésentation des résultats
GenreMéthodes
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».
En bref
Citations3 684
Publié2024
Routes d'admission2
Résumé présentoui