A279 WHY LIVER TRANSPLANT RECIPIENTS DIE: A QUALITY ASSURANCE REVIEW
Notice bibliographique
Résumé
Abstract Background Liver transplant techniques have significantly advanced over time, enhancing patient survival rates. In 2022, 99 liver transplants were performed in British Columbia (BC), ranking second in organ transplants. In BC, mortality rates for liver transplant recipients are 9.4% at one year, 15.6% at three years, 21% at five years, and 31% at ten years. However, a knowledge gap exists about the causes of post-transplant deaths in BC. This study aims to explore the primary mortality causes among these recipients over the last decade. Aims This study aims to investigate the leading causes of mortality among liver transplant recipients in British Columbia between 2013 and 2023. The objective is to identify areas for improvement and to develop strategies to decrease mortality rates. Methods We conducted a retrospective observational study including all patient deaths among liver transplant recipients in BC between January 1, 2013, to August 31, 2023. Secondary data from the BC Transplant database were used for this analysis. Results Over a ten-year period, 320 deaths were recorded in liver transplant recipients in BC. On average, patients were 53.5±12.96 years. Additionally, 60% of these individuals were male. Deaths occurred, on average, 8.6 ± 8.05 years after the patients received their transplants. Malignancy emerged as the primary cause of death, representing 24.7% of all fatalities. Together, multi-organ failure (12.5%), sepsis (11.3%), and cardiovascular issues (6.9%) made up close to one-third of the total deaths. Thirty-one patients (9.7%) died due to liver-related causes. The most common causes of graft loss were hepatitis C recurrence (6/31) and allograft rejection (8/31). Unfortunately, the cause of death was unknown in a significant proportion of patients (67/320), with nearly one-third (10/31) of all liver-related mortalities lacking a clear documented etiology. Conclusions Our study elucidated the causes of death in liver transplant recipients in British Columbia over the past decade. Cancer-related mortality, multi-organ failure, sepsis, cardiovascular events, and liver allograft failure were among the most common causes of death in this patient population. Hepatitis C recurrence and allograft rejection were common etiologies for liver-related mortality. The significant proportion of patients with undetermined or undocumented causes of death is of concern. These findings underscore the necessity for enhanced oncological surveillance, rigorous patient evaluation, and a potential re-evaluation of post-transplant care, especially in managing infections and cardiovascular health. The substantial "unknown" causes of death emphasize a need for better data capture provincially. Funding Agencies None
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».