Sex differences in the associations of human milk oligosaccharides with height and weight in breastfed Ugandan children
Notice bibliographique
Résumé
Abstract Background & Objective Human milk oligosaccharides ( HMOs) have been associated with several child growth metrics, but there was no difference in the associations according to child sex. Here, we present clinic-based cross-sectional data on the relationship between specific HMOs in the milk of Ugandan mothers and growth in their breastfed children as a group and as males and females separately. Method Human milk samples were manually collected from 127 lactating mothers. Levels of human milk oligosaccharides (HMOs) were analyzed by high-performance liquid chromatography (HPLC). Children’s weight and length were measured using a portable digital scale and length board, respectively. Weight-for-age (WAZ), height-for-age (HAZ) and weight for height (WHZ) Z scores were calculated. The relationships between HMOs and untransformed weights and heights and between WAZ, HAZ and WHZ subcategories were analyzed for all children and for males and females separately by Spearman’s correlation and Kruskal‒Wallis and Mann‒Whitney U tests. Results There were positive and negative correlations between the concentrations of specific HMOs and the heights and weights of children according to mothers’ secretor status. Tall infant stature was associated with higher concentrations of 6’SL, LSTc, DFLNH, DSLNH, LNnT and total HMOs in secretor or nonsecretor mothers; short infant stature was associated with higher concentrations of 3FL and DFLac; overweight was associated with higher concentrations of 6’SL, LSTc and LNnT in secretor and nonsecretor mothers; and normal weight was associated with higher concentrations of 3’FL. The associations between maternal HMO levels and childrens heights and weights or between the LAZ, WAZ and WHZ subcategories significantly differed between male and female children. Conclusions There are sex differences in the associations between high concentrations of some HMOs and stature and weight in Ugandan children born to secretor and nonsecretor mothers. Highlights This study showed that some HMOs are associated with child growth metrics in a sex-specific pattern. Four HMOs (3FL, DSLNT, DFLac, and 3’SL) were positively correlated with the height/length of the children. There were significant positive correlations between height/length and 3FL and DSLNT in only female children and between height/length and DFLac in only male children. DSLNT, DFLac and LSTb were positively correlated with weight in female and male children respectively. Plain Language Summary Human milk oligosaccharides ( HMOs) have been associated with growth parameters of children in the Americas, Europe and Asia. Only two such studies have been conducted in Africa. None of the studies investigated the relationship between child sex and HMO composition and growth interactions. We examined the relationship between 19 well-characterized HMOs and growth metrics and also dissected the data by infant sex. Our results show a positive correlation between some HMOs and growth indices in either female or male children only. This highlights the impact of sex differences in the relationship between specific HMOs and growth measures in children. This evidence, if validated, could inform future nutritional interventions involving combinations of HMOs as food supplements that are equally effective for both male and female children.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».