MP40-15 THE PREVALENCE OF VITAMIN D DEFICIENCY AMONG PATIENTS IN A TERTIARY METABOLIC STONE CLINIC IN ONTARIO, CANADA
Notice bibliographique
Résumé
You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation I (MP40)1 May 2024MP40-15 THE PREVALENCE OF VITAMIN D DEFICIENCY AMONG PATIENTS IN A TERTIARY METABOLIC STONE CLINIC IN ONTARIO, CANADA Mario Basulto-Martínez, Tariq Alotaibi, Jennifer Bjazevic, and Hassan Razvi Mario Basulto-MartínezMario Basulto-Martínez , Tariq AlotaibiTariq Alotaibi , Jennifer BjazevicJennifer Bjazevic , and Hassan RazviHassan Razvi View All Author Informationhttps://doi.org/10.1097/01.JU.0001008788.18007.3f.15AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Metabolic stone disease is becoming increasingly common worldwide due to a variety of factors. Vitamin D deficiency has been implicated as a variable although its exact role in the development of calcium oxalate stones is uncertain and its management controversial. In this study we sought to determine the prevalence of Vitamin D deficiency among a cohort of stone-formers in southern Ontario, Canada and compared their clinical and metabolic data with those patients with normal Vitamin D levels. METHODS: Data from patients seen in the Metabolic Stone Clinic at St. Joseph's Hospital in London, Ontario, Canada between 2005-2019 -was retrospectively reviewed. Clinical data as well results of 24 hour urine collections and serum biochemistry values were recorded. Vitamin D levels were defined as deficient if<50 mmol/L, insufficient if between 50 – 75 mmol/L, and sufficient when between 75 – 250 mmol/L. Clinical and metabolic data were compared between the low and normal vitamin D subjects. RESULTS: A total of 748 stone-formers were included. Two hundred and seventy-four patients (36.5%) had a normal vitamin D whereas 474 (63.5%) had low vitamin D [220 deficient (29.5%), and 254 insufficient (34%)]. Stone-formers with low vitamin D were younger [53 (42.5 – 61) vs 57 (44 – 67) years, p<0.001], had higher body mass index (BMI) [29.3 (25.7 – 33.3) vs 27.5 (24.3 – 31.9) Kg/m2, p<0.001], and were predominately female [55.6 vs 46.4%, p=0.019]. In the metabolic workup, stone-formers with low vitamin D had lower urinary volume [1.66 (1.24 – 2.35) vs 1.97 (1.40 – 2.70) L/day, p<0.001], slightly lower serum calcium [2.30 (2.23 – 2.36) vs 2.32 (2.25 – 2.39) mmol/L, p=0.015], and higher PTH [4.3 (3.2 – 5.8) vs 3.8 (3 – 4.8) pmol/L, p<0.001]. Among patients with low Vitamin D, 13.3% had evidence of secondary hyperparathyroidism. Stone composition was comparable between groups. CONCLUSIONS: This study of stone patients in a southern Canadian community found that Vitamin D deficiency is common. Patients with low Vitamin D levels were predominantly female, younger, and had higher BMIs than those with normal vitamin D. Moreover, low vitamin D stone-formers had lower serum calcium levels, probably due to decreases in intestinal absorption of calcium but no difference were observed in 24-h urine calcium. Higher PTH levels were observed in low vitamin D stone-formers related to secondary hyperparathyroidism. The implications of these findings are significant in that failure to correct Vitamin D deficiency in these patients in addition to potentially contributing to ongoing stone formation may also have deleterious effects on bone health. Identifying Vitamin D deficiency among stone formers in regions with seasonal variations in sunlight exposure seems warranted. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e669 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Mario Basulto-Martínez More articles by this author Tariq Alotaibi More articles by this author Jennifer Bjazevic More articles by this author Hassan Razvi More articles by this author Expand All Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».