PROGNOSTIC EVALUATION OF THE NUTRITIONAL PROGNOSTIC INDEX IN PATIENTS WITH NON-METASTATIC RECTAL CANCER
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Notice bibliographique
Résumé
Rectal cancer (RC) is one of the leading causes of cancer mortality worldwide. Recent studies indicate that systemic inflammation and nutritional status are associated with the prognosis of cancer patients. The prognostic nutritional index (PNI) has been increasingly studied as a predictor of survival outcome. However, despite these advances, there are few studies evaluating the prognostic capacity of this index in patients with RC. To analyze the impact of PNI on the survival of patients with non-metastatic RC undergoing oncological treatment. This is a retrospective, cross-sectional and analytical study. It included patients diagnosed with stage I, II and III rectal carcinoma who had been treated surgically, with or without neoadjuvant and adjuvant chemotherapy, and who were attended to at the Clinical Oncology outpatient clinic of the Hospital das Clínicas of the University of Campinas between January 2000 and December 2016. Patients were categorized into low and high PNI, according to the median of the sample. PNI was calculated using the formula: PNI = (10xserum albumin [g/dl]) + 0.005xlymphocytes/μL). Clinical variables, body composition and systemic inflammatory indices were also analyzed. Body composition was analyzed using computed tomography, and skeletal muscle compartments and subcutaneous and visceral adipose tissue were assessed using SliceOmatic software (Tomovision, Canada). Statistical analyses were carried out using Stata software version 12.0 (Stata Corp LP®). This research was approved by the UNICAMP Research Ethics Committee (CAAE: 22438319.9.0000.5404). The sample consisted of 298 patients, 118 of whom had low PNI. The group with low PNI had a lower muscle mass index (p = 0.025) and subcutaneous adipose tissue index (p = 0.044), and higher subcutaneous (p =0.049) and visceral (p = 0.012) adipose tissue radiodensity. Median disease-free survival was 24.5 months for patients with low PNI (HR 1.85; CI 1.30-2.62; p = 0.001). Patients with low PNI had a lower median disease-free survival (mDS) of 24.5 months compared to 107.4 months for the high PNI group [HR 1.85; IC 1.30-2.62; p = 0.001]. Median overall survival (mOS) was 75.3 months for the low NPI group and 140.4 months for the high NPI group (HR 1.67; CI 1.13-2.48; p = 0.011). The PNI performed at diagnosis is a prognostic tool for assessing the clinical outcome of patients with non-metastatic RC. Nutritional status and systemic inflammation are associated with survival in cancer patients. The PNI is a marker that combines both conditions and has been shown to be an important prognostic tool for desease-free survival (DFS) and overall survival (OS) in RC. The PNI is a simple, practical tool that uses low-cost clinical evaluation parameters and can therefore be easily implemented in clinical practice.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle