Acute and Chronic Endothelial Responses to Home-based High Intensity Interval Training in Healthy Older Adults
Notice bibliographique
Résumé
Advancing age is associated with endothelial dysfunction, a key early event in atherosclerosis development. Endurance exercise is recommended for cardiovascular disease prevention and some studies report endurance exercise training has beneficial effects on endothelial function in older adults. We have recently developed a supervised home-based exercise intervention using high intensity interval training on an all-extremity non-weight-bearing ergometer (HIIT-ANE). We tested the hypotheses that in healthy older adults: 1) endothelial function is improved in response to chronic HIIT-ANE, 2) the acute endothelial responses to HIIT-ANE are different in the trained and untrained states, and 3) the acute and chronic endothelial responses to HIIT-ANE are related. We assessed flow-mediated dilation (FMD), a measure of endothelial function, using brachial artery ultrasonography in twenty healthy sedentary older adults (age: 66±1, means ± SE; 11 postmenopausal women and 9 men). FMD was assessed: 1) in response to chronic HIIT-ANE (at baseline, after 8 weeks of normal lifestyle (control condition), and after 8 weeks of home-based HIIT-ANE) and 2) in response to a single session of HIIT-ANE (at pre-exercise, end of exercise and 1-hr and 24-hrs post-exercise), in the untrained and trained states. Following 8 weeks of HIIT-ANE, FMD was improved compared with baseline (3.39±0.30 vs. 4.18±0.46 %, P=0.005), but was not significantly changed from pre- to post-HIIT-ANE (3.68±0.44 vs. 4.18±0.46 %, P=0.3) or from baseline to post-control (3.39±0.30 vs. 3.68±0.44 %, P=0.4). In the untrained state, FMD was attenuated in response to a single bout of HIIT-ANE from pre- to 1-hr post-exercise (4.15±0.35 vs. 2.92±0.36 %, P=0.0004) and returned to pre-exercise level in 24-hrs post-exercise (4.15±0.35 vs. 3.98±0.40 %, P=1). In the trained state, the acute FMD response to HIIT-ANE was similar to the untrained state (P=0.6 for training state × time). The chronic change in FMD was inversely related with the acute change in FMD in the trained state (ρ=-0.70; p<0.001), but not in the untrained state (ρ=-0.12; P=0.6). Biological sex did not significantly influence the acute or chronic FMD responses to HIIT-ANE (P≥0.1). In healthy older adults: 1) FMD is improved following 8-weeks of home-based remotely supervised HIIT-ANE compared to baseline, 2) FMD is attenuated and normalized within 24 hours of a single session of HIIT-ANE, and 3) chronic changes in FMD are related to acute changes in FMD. This work was supported by the National Institute of Aging grant AG063143. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».