P-63 Prospective memory and antiretroviral medication adherence in HIV

<h3>Background</h3> Prospective Memory (ProM) is a form of episodic memory. It enables ’remembering to remember’, planning and storing intentions for the future, then executing them later. It is essential for monitoring and executing behaviours based on internal or external cues in interfering contexts. It turns out to be an important feature for functional autonomy. ProM requires activation of the medial temporal lobe and prefrontal cortex. In particular, the prefrontal cortex is the neuroanatomical substrate of executive functions. Executive functions enable us to plan, implement, and conclude goal-oriented behaviours in everyday life. People living with HIV (PLWH) may have difficulty managing daily activities. The purpose of this study was to evaluate how ProM outcomes affect the management of medical aspects in PLWH such as adherence to antiretroviral therapy (ART). <h3>Material and Methods</h3> This study assessed ProM ability in a sample of 70 PLWH with the use of the Memory for Intentions Screening Test (MIST). Cognitive domains were screened through the Montreal Cognitive Assessment (MoCA) and self-reported therapeutic adherence in the past month was collected. Exclusion criteria were age &lt;18 years and difficulties with the Italian language. <h3>Results</h3> Many of PLWH were male (91.4%, n=64), aged 46 to 55 (37.1%, n=26), with upper secondary school degree (58.6%, n=41). Most of the PLWH (68.6%, n=48) were &gt;10 years ago diagnosed with HIV and 55.7% (n=39) of them received &gt;10 years ago for the first time ART. On a scale of 1 to 10, patient-reported adherence was 7.83 (SD 1.58). The mean obtained in MoCA was 26.51 (SD 2.90). The mean obtained in MIST was 35.27 (SD 11.35). PLWH with age &gt;55 years, low education, in disease and on therapy for 1–5 years reported poor performance in ProM (p=0.023; p=0.058; p=&lt;0.001; p=&lt;0.001, respectively). A high MIST score was positively associated with high adherence to self-reported therapy (β 6.24; 95% CI 5.40/7.08; p=&lt;0.001). There was a positive correlation between MIST and MOCA (r=.286; p=0.016). The mean of the errors emerged in the MIST was 3.04 (SD 2.42). PLWH who make fewer errors reported higher adherence (p=&lt;0.001). <h3>Conclusions</h3> In conclusion, our results emphasized that ProM performance correlates with maintenance of therapeutic adherence and cognitive functioning in the normal range. Increasing age, decreasing educational attainment, and shorter time since diagnosis and shorter time on therapy seem to be factors related to lower performance in ProM. An analysis of ProM may bring out difficulties that impact with the medical management of PLWH health status. Last, assessment of ProM results should be considered in the clinical assessment of PLWH.

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