Effectiveness of Platelet Rich Plasma Injection in Comparison with Dextrose Prolotherapy on Improving Pain and Function in Osteoarthritis of Knee: A Randomized Controlled Trial
Notice bibliographique
Résumé
Background: Osteoarthritis is a common and disabling condition that represents a substantial and increasing health burden with notable implications for the individuals affected, health-care systems, and wider socioeconomic costs. Despite significant advances in science and medicine, there is no cure for osteoarthritis. Numerous treatment options have been used for management of osteoarthritis including pharmacological and invasive techniques. Regenerative therapy like Platelet rich plasma and Prolotherapy are being extensively studied due to their ability to regenerate and repair damaged tissues. Objectives: To evaluate the effectiveness of platelet rich plasma injection in comparison with dextrose prolotherapy on improving pain and function in patients with osteoarthritis of the knee. Study Design: Randomized controlled trial Methods: A single blind randomized controlled clinical trial was carried out in the Department of Sports Medicine, Regional Institute of Medical Sciences, Imphal between September 2022 to February 2024. A total of 92 patients were recruited and block of four randomization was done for allotment of the study participants. The outcome measures were visual analog scale (VAS) and Western Ontario Mac Master Osteoarthritis Index (WOMAC) score. For descriptive statistics mean, standard deviation and frequency were used. Student’s t-test and Chi square tests were used for analysis of different variables. A p-value <0.05 was taken as significant. Results: The 2 groups were homogeneous in terms of baseline characteristics like age, sex, side of affection and duration of symptoms (Table 1). The outcome variables of VAS and WOMAC score at baseline were not significant (Table 2). The mean age of the participants was 63.18 ± 5.15 in years. The mean duration of symptoms was 10.16 ± 1.22 in months. Between the groups comparison at the end of 4 weeks showed that there was no statistically significant reduction in the mean difference of outcome measures from baseline. However, at the end of 12 weeks and 24 weeks (p<0.05), there was statistically significant reduction in mean difference of outcome measures from baseline in both the groups but this was more in the Platelet rich plasma group. Conclusion: Platelet rich plasma injection was more effective in comparison to dextrose prolotherapy injections on improving pain and function in patients with osteoarthritis of knee at 24 weeks. Keywords: Osteoarthritis; Knee; platelet-rich plasma; prolotherapy;
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».