Role of Nigella Sativa (Black Cumin Seeds) as an Adjunct Therapy in Treating Severe and Critical COVID -19 Infection Compared to Those with Standard Therapy: An Open Label Randomized Clinical Trial
Notice bibliographique
Résumé
Background: During recent COVID-19 pandemic (2019-2021) clinician-researchers had been looking for effective treatment of Covid-19 infection. Nigella sativa (NS), a well-known herbal medicine, has beenused asanti-viral, anti-inflammatory, immune modulatory, anti-oxidant, broncho-dilatory, anti-histaminic, anti-tussive activitiesfor patients with mild to moderate COVID-19 infection. Our study aimed to determine the efficacy of NS for treatment of severe and critically ill Covid-19 patients as an adjunct therapy with conventional treatment. Method: This wasan open label randomized clinical trial conducted in severely and critically ill COVID-19 patients admitted into COVID ICU of United Hospital, Dhaka, Bangladesh. The study subjects were randomly divided into two equal groups: NS group in which subjects received NS orally in addition to the conventional treatment, and Control group, who received conventional treatment only. Primary outcome focused mainly on duration of ICU stay, use of mechanical ventilation (MV)/noninvasive ventilation (NIV)/ High-flow nasal cannula (HFNC) oxygen (HFNO) and mortality. The secondary outcomes were based on comparison of those above mentioned parameters between the groups (NS and Control). Results: A total of 150 subjects were enrolled according to eligibility criteria.There were 60 deaths (29 NS + 31 Cont.) and 90 survivals (46 NS + 44 Cont.). Among the survivals 16 NS subjects as opposed to 6 Cont. subjects stayed in ICU for 8 to 14 days (P = 0.043). Twenty one subjects of NS group as opposed to 8 subjects of Cont. group stayed in ICU for less than 7 days to 14 days. Whereas among subjects who died there was no significant difference in length of stay among majority of NS and Cont. subjects. NS group required significantly lower number of O2 delivery methods likemechanical ventilation (MV), noninvasive ventilation (NIV),High-flow nasal oxygen (HFNO) compared to their counterparts on Day 7 and Day 14 of stay in ICU. Conclusion: NS as an adjunct therapy with severe and critical COVID 19 infection was associated with some reduction of duration of stay in ICU but significantly less requirement of invasive and non-invasive ventilator support, high flow nasal oxygen than standard treatment group. Establishing accurately therapeutic efficacy of NS in critically ill COVID-19 patients requires placebo controlled double blind studies. Bangladesh Crit Care J September 2023; 11 (2): 75-82
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,004 | 0,006 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».