Abstract 16: Tissue Engineering Approach Using Heterogeneous Hydrogel Combined with Umbilical Cord Derived Multipotent Stem Cells for the Consequences Military Spinal Cord Injury Neurosurgical Treatment (Case Report)
Notice bibliographique
Résumé
Abstract Introduction Military spinal cord injury is a severe injury, accompanied by high mortality and profound disability. Such injuries are usually penetrating, complex, infected, require intensive treatment at the initial stages and complex reconstructive neurosurgical interventions at later stages. This problem is especially relevant for Ukraine now, during the russian attack. Objectives The objective of the study was to investigate the short-term effect and safety of tissue engineering approach using umbilical cord arteries derived multipotent stem cells (UCA-MSCs) and heterogenous hydrogel for the consequences of military spinal cord injury neurosurgical treatment. Methods Patient B, the soldier of the National Guard of Ukraine, born on 1984, was wounded on 07/27/22 during a battle near Bakhmut. At 07/28/22 spinal cord decompression and fixation surgery was performed at the lower thoracic level (Th10). The patient had lower paraplegia (ASIA A), and neurogenic bladder. Complete anatomical and functional spinal cord transection below the Th10 level was confirmed. The patient was offered treatment in the frame of a research program "To investigate the effectiveness of regenerative cell technologies in the neurosurgical treatment of patients with demyelinating diseases of the CNS and cerebral palsy. № 0119U000112". UCA-MSCs for this case were isolated from a healthy human umbilical cord and had characteristics according to the minimal criteria of MSC. The hydrogel (poly[N-(2-hydroxypropyl)-methacrylamide]) is a commercial preparation synthesized in the laboratory of E. Pinet (FISO Technologies Inc., Quebec, Canada) by heterogeneous polymerization and association. 12/06/23 operation was performed: myeloradiculolysis, excision of areas of the glial scar of the spinal cord and filling of the defect with a heterogeneous hydrogel combined with UCA-MSCs. Results On the 6th months of observation, the patient has no infectious and inflammatory complications, and elements of deep sensitivity appeared in the proximal areas of the buttocks. No adverse effects during the observation period were recorded. Discussion More cases are needed to determine this method's safety and effectiveness, but early results are promising. A careful selection of patients is necessary for the use of this method, namely: confidence in the complete anatomical and functional transection of the spinal cord and the patient's informed consent for treatment.
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Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».