Editorial: HLA in personalized medicine
Notice bibliographique
Résumé
Editorial on the Research Topic HLA in personalized medicine HLA traveled a long distance from initially being regarded as a transplant antigen to becoming a molecule of interest in 21st century for the development of novel diagnostics and therapeutics in the treatment of human diseases, vaccine design, pharmacogenetics, and genomics.The proteins encoded by genes in the Human Leukocyte Antigen (HLA) complex regulate the innate and adaptive arms of human immune responsiveness through antigen recognition and presentation, inflammation regulation, and the complement system, and the impact of this region is well documented in solid organ and hematopoietic stem cell transplantation and various immunemediated conditions.In the 21st century, the role of HLA in personalized medicine is tailored with the advent of massive parallel sequencing technologies such as targeted sequencing by nextgeneration sequencing (NGS) and third-generation sequencing (TGS), which opens new frontiers in the development of predictive and preventive medicine.The goal of our Research Topic was to collect articles that provide the most cutting-edge research on the application of the concept of HLA in personalized medicine in the context of clinical allotransplantation and cancer.The Research Topic of articles in Frontiers in Genetics under the specialty Research Topic of "HLA in Personalized Medicine" presents three original research papers, one case report, and one perspective article.The Research Topic was open between 9 September 2023, and 13 February 2024, and five manuscripts were accepted for publication.The Research Topic of this Research Topic provides an important insight into the application of the concept of HLA in personalized medicine by presenting articles that demonstrate the significance of heterozygous advantages in cancer, the application of vaccination with a cocktail of HLA class I and II peptides in treating metastatic cancer, HLA-B and TAP transcriptional silencing in pediatric solid cancers, the utility of race, ethnicity, and ancestry in transplant donor registries, and the clinical relevance of HLA-DQ eplet mismatches in the management of immunosuppression in retransplant candidates.The original research study performed by Tsai et al. tested the hypothesis that the increased heterozygosity at HLA loci is correlated with a diminished risk of developing colorectal cancer (CRC).This study found that individuals with all heterozygous genotypes at HLA class I and class II genes had a decreased risk of CRC.Similarly, individuals with combined HLA class I and class II heterozygous genotypes had significantly reduced odds of developing CRC as compared to those with 0 or one heterozygous genotype.This study further examined whether germline HLA diversity is linked to tumor T cell landscape.Although the differences were not statistically significant, HLA class I and/or II diversity was correlated with higher T cell receptor (TCR) abundance and reduced TCR clonality.This research study highlighted the heterozygote
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,002 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».