Absence of Lymphogranuloma Venereum Among Men Who Have Sex With Men With Rectal Chlamydia trachomatis Infections Within an HIV Preexposure Prophylaxis Program in Hanoi, Vietnam
Notice bibliographique
Résumé
Dear Editor, We read with great interest the study by Gupta et al.1 on the increasing number of lymphogranuloma venereum (LGV) cases in British Columbia, Canada. The LGV infections were primarily among men who have sex with men (MSM) on HIV preexposure prophylaxis (PrEP) and were more likely to be asymptomatic. Although considered to be rare in high-income countries, LGV cases disproportionately affect MSM and are being observed with increasing frequency among HIV-uninfected men on HIV PrEP.2–5 Lymphogranuloma venereum is considered endemic to parts of Southeast Asia, yet epidemiologic data from the region are sparse. One recent report among MSM in Taiwan found that the prevalence of LGV rectal infections was 1.6%.6 In Vietnam, we have found a high prevalence of rectal Chlamydia trachomatis infections among MSM, but the prevalence of LGV is not known.7 Given increasing reports of LGV in other settings, we sought to understand the prevalence of LGV among MSM in an HIV PrEP program in Hanoi, Vietnam. From January 2022 to May 2023, HIV PrEP program participants in Hanoi who were male and reported having sex with men or transgender women in the prior 12 months were enrolled in a study on the prevalence of C. trachomatis and Neisseria gonorrhoeae infections. Participants self-collected rectal, pharyngeal, and urine samples for testing by nucleic acid amplification testing using either the Roche cobas CT/NG or Abbott m Alinity STI assays. Remnant specimens were stored at −80°C, and a subset was selected from available rectal specimens with C. trachomatis to undergo LGV testing. DNA extraction was performed using QiaAmp Mini Kit (Qiagen, Hilden, Germany), with internal controls. The non-LGV/LGV real-time polymerase chain reaction assay was conducted using a 168-bp fragment of the pmpH gene for amplification, as described previously.8 The prevalence of rectal C. trachomatis infections in the parent study was 14%. In total, 90 rectal specimens with C. trachomatis infections were selected for LGV testing, with 31% being from participants reporting rectal symptoms in the prior week. All the specimens were negative for LGV by real-time polymerase chain reaction. Internal controls were positive for DNA extraction for all specimens; 8 specimens (8.9%) were negative for both LGV and non-LGV, suggesting a low amount of C. trachomatis DNA. Screening for LGV in rectal C. trachomatis infections among 90 MSM in an HIV PrEP program in Hanoi, Vietnam, did not identify any LGV infections. Despite the increasing prevalence of LGV infections among MSM in some settings, there does not appear to be a substantial prevalence in our setting. Recent reports from China and Thailand also did not show LGV infections in MSM populations.9,10 The absence of LGV infections in our study might be the result of the relatively limited number of samples tested or reflect the study setting, which was one HIV PrEP program in Hanoi, and might not represent other LGV infections in other settings. Additional research is needed to more comprehensively understand the epidemiology of the LGV infections in the region, particularly among populations living with HIV and on HIV PrEP. Tien V. Quang, MS Phacogen Institute of Technology Hanoi, VietnamHao T.M. Bui, PhD, MPHLoc Q. Pham, MD, PhDGiang M. Le, MD, PhD Center for Training and Research on Substance Abuse—HIV Hanoi Medical University Hanoi, VietnamHoi T. Le, MD, PhD Phacogen Institute of Technology Hanoi, VietnamJeffrey D. Klausner, MD, MPH Department of Population and Public Health Sciences Keck School of Medicine University of Southern California Los Angeles Los Angeles, CAPaul C. Adamson, MD, MPH Division of Infectious Diseases David Geffen School of Medicine University of California Los Angeles Los Angeles, CA [email protected]
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».