PSVIII-15 Inoculating suckling beef calves with a bovine-derived blend of <i>Lactobacillus spp.</i> exhibited psychobiotic potential for stress mitigation
Notice bibliographique
Résumé
Abstract The term “psychobiotics” refers to beneficial microbiota, such as Lactobacillus spp., which positively influence the hypothalamic-pituitary-adrenal axis, immune response, and inflammation via the gut-brain axis. While these bacteria are recognized for benefiting their host, research on their application in cattle is limited. Therefore, this study evaluated the impacts of administering a bovine-derived mixture of Lactobacillus spp. during early life to beef calves as a strategy to modulate long-term gut microbiota and potentially alleviate weaning stress. Crossbred beef calves [n = 32; 66 ± 11 kg of body weight (BW); 60 ± 6 d of age] were stratified by age and sex and randomly assigned to receive either two doses of an orally-administrated Lactobacillus cocktail (n = 16; 10^9 CFU; LAB) or saline solution (n = 16; CON) 3-d apart. After first inoculation (d 0), cow-calf pairs were allocated to four different paddocks (two/treatment) for 15 d, and then, both treatments were placed in a single pen until weaning, at ~202 d of age. After weaning, calves from both treatments were housed in a single pen. Body weight was recorded, and blood samples were collected on d 0, 3, weaning, and 3- and 14-d post-weaning (PW). Data was analyzed as a completely randomized design. Plasma concentrations of phenylalanine (P = 0.04) were greater, while tyrosine (P = 0.09) and lysine (P = 0.07) tended to be greater in LAB compared with CON calves. Furthermore, LAB calves had reduced plasma concentrations of heat shock proteins 70 (P = 0.04; 0.02 vs. 0.13 ng/mL) and cortisol (P = 0.03; 108.1 vs. 121.1 ng/mL). A tendency for a treatment × day interaction was detected (P ≤ 0.07) for white blood cells (WBC), where CON calves had decreased WBC and lymphocytes (P = 0.05) on d 0 compared with LAB. Treatment did not impact average daily gain and final BW (P ≥ 0.26). Regardless of treatment, weaning stress increased plasma concentrations of haptoglobin (P < 0.01), serotonin (P = 0.06), and the counts and percentages of monocyte, eosinophils, and basophils (P < 0.01), whereas gamma-aminobutyric acid, aspartate, and insulin-like growth factor-1 concentrations decreased (P < 0.01) on d 3 PW. In conclusion, early life inoculation of suckling beef calves with a Lactobacillus spp. mixture presents promising effects on mitigating some physiological stress indicators, as indicated by decreased cortisol and heat shock protein concentrations and greater concentrations of amino acids precursor of central catecholamines. These preliminary results suggest that psychobiotics could offer a promising avenue for stress management in beef calves, potentially with long-term effects. This emphasizes the importance of future research on other physiological and behavioral indicators of weaning and other stressors to fully elucidate the potential benefits of psychobiotic inoculation in livestock management.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».