361 Evaluating the effect of liver copper concentration on lubabegron fumarate-induced performance and carcass characteristics of finishing steers
Notice bibliographique
Résumé
Abstract The objective of this study was to evaluate the effect of copper (Cu) status on response to lubabegron fumarate (Experior, Elanco, Greenfield, IN). Angus crossbred steers [n = 48; body weight (BW) = 469 ± 31 kg] were enrolled in a 77-d finishing study, housed in pens of 6, with a GrowSafe bunk (GrowSafe Systems, Ltd, Airdire, AB, Canada) in each pen and implanted (Revalor-200, Merck Animal Health, Madison, NJ; 200 mg TBA + 20 mg E2) on d 0. A 2 × 2 factorial arrangement was applied to Cu status (deficient, DEF, no supplemental Cu; or adequate, ADE, 10 mg supplemental Cu/kg DM as CuSO4) and Experior (36 mg·steer⁻¹·d⁻¹, EXP; or no Experior, NOEXP). A prior trial resulted in steers with distinct liver Cu (DEF and ADE were 42 ± 21 and 193 ± 31 mg Cu/kg DM, respectively). Experior was fed from d 37 to d 73, and cattle harvested on d 78. Body weights were collected on d -1, 0, 37, 55 (mid-Experior), 76 and 77. Blood was collected on d 0, 37, 55, and 76 for serum urea nitrogen (SUN), non-esterified fatty acids (NEFA), glucose, and insulin. Data were analyzed in Proc Mixed of SAS as a factorial design, with steer as the experimental unit (n = 12 per treatment). From d 0-37, DEF daily gain and feed efficiency (G:F) were greater than ADE (P < 0.01), while dry matter intake (DMI) did not differ (P = 0.36). Overall DMI was greater in ADE than DEF (P = 0.04) and not affected by Experior (P = 0.13). Carcass-adjusted average daily gain was not affected by Cu or Experior (P ≥ 0.21). Deficient steers had greater carcass-adjusted G:F than ADE (P = 0.02). Hot carcass weight was greater in EXP (P = 0.04), but post-hoc analysis of the Cu x Experior effect (P = 0.2) reveals this was driven by DEF-EXP (15 kg over DEF-NOEXP) rather than ADE-EXP (4 kg over ADE-NOEXP). Marbling tended to be greater in ADE (P = 0.06) and was unaffected by Experior (P = 0.14). The revised quantitative insulin sensitivity check index displayed an EXP x Day effect (P < 0.01) where NOEXP was consistent across days and EXP had greater insulin sensitivity during the Experior period. Serum urea nitrogen was affected by Cu × Experior × Day (P = 0.01), where DEF-NOEXP had lesser d 0 SUN than all others, and EXP decreased on d 55 while NOEXP increased steadily during the finishing phase; by d 76 DEF-EXP remain lesser than NOEXP treatments with ADE-EXP being similar to all others. These data suggest Cu concentration influences steer response to lubabegron fumarate, and more research is needed to determine the cause of this.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,004 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».