Multivalent effect on chronic back pain: results of randomized clinical trials of Dorsumio
Pourquoi ce travail est dans la base
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Notice bibliographique
Résumé
Treatment of chronic back pain (CBP) continues to pose a pressing problem due to its nonspecificity and mixed nature. This paper presents the results of clinical trials (CT) of phases II and III on the efficacy and safety of a new drug for CBP treatment — Dorsumio (mirtazapine 15 mg + tizanidine 6 mg). Material and methods. Patients with moderate CBP and mild or moderate depression participated in CTs phase II and III. In CT phase II, a comparison was made with the original drugs mirtazapine and tizanidine, in CT phase III — with tizanidine. The primary endpoints in CTs were: a change in the severity of pain on the Numerical Rating Scale and change in the total score on the Beck Depression Scale (BDS) after 30 days of therapy (CT II) and the proportion of patients achieving ≥50% pain reduction on the NRS scale after 22 days (CT III). The secondary endpoints in CTs were: a dynamics of pain severity according to the NRS (on days 8, 15, 22, 30 in CT II), the proportion of patients with a 30% and 50% reduction in pain severity according to the NRS (on day 15 in CT II), dynamics of the total score according to the BDS (on day 30 in CT II), dynamics of the fingertip-to-floor test result (on days 15, 22, 30 in CT II), dynamics of the index according to the Oswestry disability questionnaire (at the day 30 in CT II), changes in the severity of pain according to the NRS (on days 22, 29 in CT III) in the Dorsumio and tizanidine treatment groups, the proportion of patients achieving ≥50% pain reduction according to the NRS and the dynamics of the total score on the short-form McGill Pain questionnaire (on day 29 in CT III), the dynamics of the total score according to BDS (on days 29, 56 in CT III). Results. Dorsumio significantly reduced pain severity by 86.7% compared to baseline (according to NRS) and by 74.5% compared to baseline (according to the short-form McGill questionnaire) after 30 days. Dorsumio significantly reduces the severity of pain by 50%, while the proportion of patients is 73% after 2 weeks of therapy (according to the NRS). Over the same period of therapy, the proportion of patients with a 50% reduction in pain severity in the tizanidine group was 28% less and in the mirtazapine group it was 40% less. Dorsumio significantly reduced the severity of depression by 60.5% after 4 and 8 weeks of treatment (according to the BDS). The early analgesic effect of Dorsumio in patients with CBP was significantly different from that for tizanidine and mirtazapine,and was observed after 8 days of therapy (reduction in pain severity by 38.6%). The difference in pain relief after 8 days of treatment was 13.1% when comparing changes in mean scores from baseline in the Dorsumio and tizanidine groups, and 14.3% when comparing the Dorsumio and mirtazapine groups. Dorsumio facilitated physical mobility (according to the Oswestry disability questionnaire) by 82% after a month of treatment, which is 16.4% more than in the mirtazapine group. The tolerability of Dorsumio was comparable to that of its individual components used in monotherapy.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,205 | 0,087 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,004 | 0,003 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle