PROPHYLAXIS FOR INHERITED DEFICIENCY OF FACTOR X (PROTECT-X): A SYSTEMATIC REVIEW
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Notice bibliographique
Résumé
Hereditary factor X (FX) deficiency (FXD) is a rare autosomal recessive bleeding disorder. The reduced or absent plasma FX clotting activity leads to spontaneous hemorrhages or bleeds after minor trauma. FXD severity varies among mild (FX 6%‒10%), moderate (FX 1%‒5%), and severe (FX < 1%), and the bleeding risk is inversely proportional to the residual plasma FX clotting activity. Therapy is based on treating (episodic) or avoiding (prophylaxis) bleeds with clotting agents, such as fresh frozen plasma, Prothrombin Complex Concentrate (PCC) or partially activated PCC, and exogenous FX replacement. We performed a literature systematic review to evaluate the efficacy/effectiveness and safety of prophylaxis against bleeds in people with FXD (PwFXD) compared to exclusive episodic treatment or prophylaxis with a different clotting agent. The systematic review was registered in PROSPERO (CRD42024535021) and is under conduction based on the PRISMA 2020 statement. Literature assessment was performed on 06/05/2024 based on strategic search directed to specific databases (PubMed, Embase, and LILACS). No language nor publication period were used as restrictions. Randomized controlled trials, non-randomized controlled trials, observational studies (prospective cohort, retrospective cohort, and cross-sectional), and case reports that evaluated the prophylaxis in PwFXD were included. Any publication reporting on prophylaxis in PwFXD was included. Reports on prophylaxis during surgical procedures were excluded. In addition, prophylaxis-referenced citations from the included publications and from the excluded reviews published within the previous 10 years were evaluated for eligibility. In addition to metadata, we will extract data on bleeds, clotting agent consumption, quality of life, and adverse events (e.g., death, discontinuation of treatment, and development of anti-FX antibodies). Meta-analysis will be performed when feasible. Study quality and risk of bias evaluation will be performed using the Newcastle-Ottawa Scale. The literature database search and the manual citations search retrieved 4,409 and 134 records, respectively. After selection according to the inclusion and exclusion criteria, 26 publications were included. The included publications were published from 1992 to 2024, only in English. The studies were performed mainly in Europe and North America. Designs comprised interventional (6, 23.1%) studies, observational (9, 34.6%), and case reports/series (11, 42.3%). Of 413 participants described, 395 (96%) were PwFXD, of whom 117 (29%) received prophylaxis. Final data will be reported in the congress. It is expected that our findings contribute to the management of PwFXD.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,004 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle