LUSPATERCEPT UTILIZATION PATTERNS IN LOWER-RISK MYELODYSPLASTIC SYNDROMES: FINDINGS FROM A MULTINATIONAL MEDICAL RECORD REVIEW STUDY
Notice bibliographique
Résumé
Limited evidence exists from routine clinical practice on patient (pt) characteristics and treatment (tx) patterns in pts treated with luspatercept for lower-risk myelodysplastic syndromes (LR-MDS). This study aimed to describe the baseline demographic and clinical characteristics and patterns of therapy in pts with LR-MDS receiving tx with luspatercept in Canada, Germany, and Spain. This was a noninterventional, retrospective medical records review study. Pts aged ≥18 years, diagnosed with LR-MDS, and treated with luspatercept after its approval in the respective countries were identified for study inclusion by participating hematologists/hem-oncologists (data abstraction period: October–November 2023). Abstracted data on baseline pt characteristics (eg, demographics, comorbidities, genetic risk factors) and luspatercept tx patterns (eg, line of therapy, dosage, time to tx discontinuation) were analyzed descriptively. Findings reported here are based on interim data collected through November 2023 for Canada, Germany, and Spain. Data were abstracted by 47 participating physicians for a total of 114 eligible pts (56 Germany, 52 Spain, and 6 Canada). Median age was 71 years (range, 40–92), 59.6% of pts were male, and 92.1% were White. Revised International Prognostic Scoring System (IPSS-R) risk status was Very low or Low for nearly two-thirds (64.9% [among 111 pts with recorded data]) at LR-MDS diagnosis and for approximately half (53.8% [among 65 pts with recorded data]) at luspatercept initiation. Luspatercept use was most common in the second line (2L, 57.9%), followed by first line (1L, 33.3%), and third or later line (3L+, 8.8%). Among previously treated pts (n = 76), almost all received erythropoietin-stimulating agents (94.7%) before initiating luspatercept. Median follow-up duration was 21.5 months from LR-MDS diagnosis. Median time from LR-MDS diagnosis to luspatercept initiation was 10.7 months (median time to initiation in 1L was 0.9 months). Median dose at luspatercept initiation was 1 mg/kg per administration among those with known dosing data (n = 103), with a majority (91.3%) receiving a 3-weekly cycle. Approximately 17.5% (n = 20) received a dose increase. The median dose as of the last follow-up, reported for 17 pts with a dose increase, was 1.3 mg/kg per administration, cycled every 3 weeks. Median follow-up duration from luspatercept initiation was 8.9 months, and median duration of therapy over this period was 8.7 months. Overall, 14.9% (n = 17) discontinued therapy, and of those with known dosing information (n = 15), 40% had a dose escalation before discontinuation. This analysis of pts with LR-MDS receiving luspatercept in Canada, Germany, and Spain shows that one-third of pts received luspatercept in 1L, patients were followed for approximately 2 years (21.5 months) from LR-MDS diagnosis, and only 40% of pts who discontinued therapy had a dose escalation before discontinuation, suggesting that a better understanding of dose escalation may be needed. This study provides early insights into the prevailing patterns of luspatercept utilization in routine clinical practice in Canada, Germany, and Spain and is expected to inform ongoing and future evaluations of this tx option for pts with LR-MDS. The study was supported by Bristol Myers Squibb. This abstract was previously presented at the EHA Annual Congress (Díez Campelo M, et al. HemaSphere 2024;8[suppl 1]:P1909).
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,007 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».