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Anemia Acuity Effect on Transfusion Strategies in Acute Myocardial Infarction
François Martin Carrier, Howard A. Cooper, Gerard Portela, Marnie Bertolet, Gilles Lemesle, Micah T. Prochaska, Sarang Kim, John H. Alexander, Ian Crozier, Grégory Ducrocq, Alexandre Schaan de Quadros, Akshay Bagai, Marianna Deway Andrade Dracoulakis, Mina Madan, Maria M. Brooks, Jeffrey L. Carson, Paul C. Hébert, Fei Chen, Patrick Desanto, Karen Dragert, William J. Kostis, Deborah McCloskey, Helaine Noveck, Sheila Redding, Ami Patel, Shahab Ghafghazi, Sharon Vincent, Hardeep Dholiya, Dinesh Kalra, Jennifer A. Moore, Mallory Hatfield, Syed Haidry, Ahmed Hassanin, Risheek Kaul, Fnu Namrata, Parija Sharedalal, Jayakumar Sreenivasan, Jasjit Bhinder, Mohammed Hasan Khan, Anna Koulova, Behram Mody, Yogita Rochlani, Anuritha Tirumani, Frances O. Wood, Rhonda Norton, LaMonica Daniel, Mark Menegus, Samanta Baboolall, Sheila Davila, Noelle Manning, Mollie Machado, Judah Rauch, Angeline Camilo, Estefanía Hernández, Muhammad Iqbal, Ervin Mazniku, O Ramírez, Veronica Day, Barry F. Uretsky, Jesse Byrd, Kristin Miller, Srikanth Vallurupalli, Gregory Maniatis, Richard Dima, Roman Royzman, Sean Taylor, Amanda Tice, Brandon Dilluvio, Luis Gruberg, Puneet Gandotra, Rachel Gentles, Barbara Shannon, Maria Masih, Robert O. Roswell, Alana Gulliver, Meriton Ruhani, Emily Strober, Samia Tamazi, Adam Gershon, Kristie Coleman, Bernard Kadosh, Rajiv Jauhar, Harsha Adnani, Kyle Agostini, Loukas Boutis, Ian Dalangin, Barry H. Kaplan, Jae Sung Lee, Perwaiz Meraj, Riona Timmons, Carl D. Reimers, Craig Basman, Umar Rashid, A. Garvey Rene, Asha Mellor, Karen duBourg, Joseph S. Rossi, Ryan Orgel, Emma Reynolds, Tatum Scholl, Janet R. Bogan, Olivia Bogdan, Matt Cavender, Gaetana Cosentino, Gabriela De Jesus, Megan Gonzalez, Julia Hoang, Emma Kleemann, Deanna Ravenscraft, Teresa L. Reed, Joshua Roark, Samantha Smith, Kaitlyn Sternat, Oreyane Tate, Tyrone Wade, Hope Wolf, Farhad Abtahian, Megan Littleton, Kayla Malchoff, Kelly Mohr, Emily Pierce, Jennifer LaLonde, Kellie Sherron, Tia Albro, Patty Noll, Meechai Tessalee, Claudia Eaton, Gregory W. Barsness, Diana Albers, Jacob C. Jentzer, J. Dawn Abbott, Kelly Franchetti, Catherine Gordon, Herbert D. Aronow, Ellen Cerullo, Lori-Ann Desimone, Elizabeth C. Nowak, Elizabeth Coccio, Kodangudi B. Ramanathan, Adedayo Adeboye, Ashley Armstrong, Lillie Johnson, Anh-Phuong Pham, Rahman Shah, Mark Schmidhofer, M. J. ALBRIGHT, Melissa Enlow, Barinder Hansra, Tracy L. Nicholson, Catalin Toma, Darrell J. Triulzi, Megan Basch, Amanda Bollino, Laurie Dennis, Kathy S. Puntil, Chelsey Snyder, Linda Spearman, Jenny Whitehead, Friederike K. Keating, Bhisham Harchandani, Meghan Sesera, Jonathan Halevy, Molly Raftery, Marilynn Roth, David S. Kountz, Michael Carson, Lynda Argenzio, Michael C. Kontos, Melissa Sears, Laura Johnson, Mansoor Qureshi, Ahmad Mizyed, Sarah Whitsett, Kristina Wippler, Jay S. Raval, Stacey Clegg, Warren K. Laskey, Judith Mondragon, Tamar S. Polonsky, Matthew L. Carlson, Catherine Drovetsky, Joseph Gutbrod, Maud H.E. Jansen, Tharani Jeyaram, Noora Reffat, Rajesh Gupta, Mujeeb Sheikh, Meghan Moore, Kristin Fischer, Jennifer Gilmore, Christina Sattler, Stephanie Frank, Lynne Uhl, Kalon K.L. Ho, Hannah Hunsaker, Jenifer Kaufman, Lauren Lanuto, Jordan B. Strom, Patricia Tyler, Paul Mullen, Jennifer M. Ratcliffe, Brandy Williams, Arthur Bracey, Araceli Boan, Gilberto De Freitas, Samantha Macias, George Younis, William Matthai, Sameer Khandhar, Karen Maslowski, Nilay Patel, Sammy Elmariah, Christopher P. Stowell, David M. Dudzinski, Roukoz Abou-Karam, Lina Fu, Paris Jamiel, Cristina Brueggeman, Gregary Marhefka, Blaire Cain, Barbara Gallagher, Perry Weinstock, Janah Aji, Brian Corbett, Elias Iliadis, Patricia Niblack, Jeffrey Ogbara, Simon Topalian, Leana Abreu, Amanda Logan, Amanda Salvatore, Erin Siderio, William Lawson, Ruth J. Stein, Samantha Weber‐Fishkin, Norma Keller, Eugene Yuriditsky, Carlos L Alviar, Sripal Bangalore, Maria Daly, Dharshini Sivakumaran, Raven R. Dwyer, Carolina Rodríguez Álvarez, Shuaib Ahmad, Michael A. Thomas, Allison Schley, Gau Shoua Vue, Claudia P. Hochberg, Omar K. Siddiqi, Denise Fine, Alice Jacobs, Joshua Schulman‐Marcus, Mikhail Torosoff, Wendy A. Stewart, Michael Gitter, Barbara Shimada-Krouwer, Leanne Harmann, Matthew S. Karafin, Pranitha Patlolla, Julie Werra, Mary Wexler, Xuming Dai, Jackson Ng, A. Adam, A. Cherian, Jay H. Traverse, Carina Benson, Rose Peterson, Amy McMeans, Elizabeth A. Reedy, Andrea Sarafolean, Eric McCamant, Jason Scott, Michelle Jordan, Kay Knepper, Jennifer Nguyen, Deborah Ramsey, Tara Tawil, Todd Wood, Dhvni Dave, Heidi Testa, Rajesh V. Swaminathan, Sunil V. Rao, Kathy Aristy, Mitchell W. Krucoff, Thomas J. Povsic, Andrew M. Goldsweig, Shahbaz A. Malik, Yiannis S. Chatzizisis, John V. Higgins, Poonam Velagapudi, Dávid Barton, Jeremy Stone, Samer Sayyed, Arav Jhand, Daniel Johnson, James Sullivan, Furquan Khattak, Kara Stout, Jennifer Nickol, David S. Shin, Mansi Oberoi, Taylor Johnson, Melissa D. Howard, Zaria Starfeldt, Ryan Ruskamp, Nathan Muhn, C. Pacheco, Tyler Patterson, Angie Adler, Andrew P. DeFilippis, Kárita Cláudia Freitas Lidani, Cassandra Reynolds, Nicholas Brooks, Stephan Bierenga, Adam C. Salisbury, Jamie Hall, David Landers, Robert C. Hendel, Wilson Ginete, Ganesh Raveendran, Craig Hudak, Ramin Ebrahimi, Richard G. Bach, Margie Palazzolo, Kimberly Striler, Paolo Mascari, Hal S. Wasserman, Joseph M. Delehanty, Raj C. Shah, Lesley A. Schmaltz, Steve Attanasio, Sorin J. Brener, Brendan Duffy, Paul Grunenwald, Jonathan Doroshow, Muhammad Abubakar Shakir, Adriano Caixeta, Attílio Galhardo, Paula Santiago Teixeira, Joyce Umbelino S. Yamamoto, Dalton Bertolim Précoma, Cristina Correa, Maynara Martins, Carlos Rochitti, Camila Richter, Carlos Alberto Kenji Nakashima, Eliane Sehnem, Frederico Toledo Campo Dall’Orto, Gislayne Rogante Ribeiro, Ricardo Reinaldo Bergo, Claire Marie Pedroso Dias Corsini, Kemilys Marine Ferreira, Pedro Beraldo de Andrade, Róbson Alves Barbosa, Natalia Alvaia, Rodolfo Dourado, Jéssica Ribeiro, Camilla de Oliveira Vieira, Aline Giacomo, Mariana Lopes, Lília Nigro Maia, Osana Costa, Paulo Jhones Dutra, Danieli Frassatto, Maria Angélica Lemos, Thaise Loverdi, Marcelo Arruda Nakazone, Nadielly Prado, Osvaldo Da Silva Júnior, Natalia Cordeiro da Silva, Sidney Gomes, Anna Helena Felipe Pereira Centurione, Luiz Eduardo Fontelles Ritt, Queila Borges de Oliveira, Karina De Carvalho Cordeiro, Alexandre Schaan de Quadros, Giulia Bonatto, Bruna Machado, Silvia Poleth, Camille A. Correia, Raphael Boesche Guimarães, Israel Cabral, Dário Celestino Sobral Filho, Maria Cleide Freire Clementino da Silva, O Carvalho, José Gildo de Moura Monteiro Júnior, Sergio Nascimento, Fernando De Martino, Paula Miranda Camasmie, Leonilda Castanho Da Rocha, Pâmela Assunção, Fábio Rodrigues de Oliveira, Paulo Henrique Maia Vilela, Rodrigo Cunha de Sousa, Estêvão Lanna Figueiredo, Fernando Carvalho Neuenschwander, Cristina Carvalho Neuenschwander, Izabela Rodarte Falco, Arlete Matos, Thao Huynh, N Sánchez Fuentes, Amanda Barnett, C. Boudreault, Greg Schnell, Leslie Poirier, Darlene Ramadan, Manohara Senaratne, Bernadette Fernando, Mike Hanninen, Anushka Jayasekara, Janek Senaratne, Lalantha Coonghe, Sharada Manchikanti, Gamintha Nanayakkara, Vikas Tandon, Patricia Power, Ryan Proc, Kajenny Srivaratharajah, Lisa Trombetta, Pablo Mendoza, Krysten Gregus, Jacqueline Hare, Kelly Lawrence, Ameen Patel, Shirley Pettit, Jocelyn Kuber, Summer Nasr, John Neary, Muammar Abdulrahman, David Cohen, Yola El Dahr, Faraaz Quraishi, Laura Tomat, Spencer Wikkerink, David Laflamme, Miriam Schnorr Meloche, Christel Simard, Lise Blais, Jean‐Pierre Déry, Christina Avena-Cyr, Mélanie Roy, Micheline Charron, Kevin R. Bainey, Norma Hogg, Suzanne Welshsan, Richard Haichin, Coralie Gasc, Reza Sahebjamei, Fatemeh Vaezi-Poor, Payam Dehghani, Sabiha Sultana, Ata ur Rehman Quraishi, Hussein Beydoun, David Fillmore, Deborah S. Keller, Nick Bartlett, Brian J. Potter, Fatna Benettaib, Adriana Carbonaro, Isabelle Chausse, Katherine Coutu-Beaudry, Maya Hatwik, Martine Lebrasseur, Cindy Prié, Caroline Vallières, Dounia Boumahni, Genevieve Dallaire, Renée Duclos, Ali Ghamraoui, Mélissa Gagnon-Hamelin, Emilie Sau, Michael Goldfarb, G Ricafort, Claudine Robert, Sophie Florencio, Christopher B. Fordyce, Jackie Chow, Reilly Ische, Ngaire Meadows, Andrew Starovoytov, Sydney Thorsteinsson, Naomi Uchida, Lily Cai, Shirley Geok‐lin Lim, Jenny Petterson, Himantha De Silva, Stella Chan, Celine Yan, Ying Tung Sia, Miguel Barrero, Ricardo Costa, Ariel Diaz, Martin Faucher, Carl-Éric Gagné, Jean-François Naud, Philippe Rheault, Yanek Pépin‐Dubois, Vincent Spagnoli, Isabelle Roy, Benoit Daneault, Julie Caron, Sara Jabeen, Nidhya Lakshmi Thulasiraj, N. Alvarez Garcia, Suneet Khurana, Terry McPherson, Rehana Bajwa, Cassie Wagner, John Ducas, Kunal Minhas, Kiran Atwal, Malek Kass, Stephen Allan Schaffer, N. Brass, Rebecca Cairns, Anna S. Law, Mona Doorsian, Neil Fam, Jan O. Friedrich, Andrew Baker, John Graham, Michael Kutryk, Gyan Sandhu, Imrana Khalid, Marlene Santos, Simon Robinson, Kim M. Allen, Noreen Lounsbury, Sheryll Sorensen, Elizabeth C. Martin, Vladimír Džavík, Anna Tran, Razi Khan, Nicolas Michaud, Philippe Gabríel Steg, Arthur Darmon, Quentin Fischer, Neila Sayah, Hélène Abergel, Catherine Bouffard, Audrey Cailliau, Axelle Fuentes, Nicolas Pham, Alexandre Gautier, Jules Mesnier, Étienne Puymirat, Mélissa Sriwaran, Rachel Elysee, Antoine Fayol, Amandine Grelier, Nesrine Hafsi, Hasina Rakotosamimanana, Victoria Tea, Sarah Arab, Hinde Irekti, Anne Druart, Isabelle Pilat, Basile Verdier, Émile Ferrari, E Fourrier, Mohamed Labbaoui, Nassim Redjimi, Amina Zamiti-Smondel, Rabab Bencherif, Benoît Lattuca, Elodie Delelo, Johanne Silvain, Olivier Barthélémy, Fatima Benattia, Perrine Devos, Soraya Merbah, Juliane Posson, Nikki Procopi, Thomas Wallet, Michel Zeitouni, Arnaud Ferrante, Camille Granger, Stéphane Manzo‐Silberman, Tomy Salloum, Gérald Vanzetto, G. Barone Rochette, Sara Blanc Vannet, Clémence Charlon, Océane Crebier, Stéphanie Marlière, Pauline Peretout, Julie Hildt, Laura Cetran, Thomas Baudinet, Pierre Coste, Amandine Ruissel, Marine Servat, Thibault Lhermusier, Frédéric Bouisset, Francisco Campelo-Parada, Kimberly Lemoine, Mouin Nasr, Marine Poisay, Clément Servoz, Stéphanie Tribeau, Yves Cottin, F. Bichât, M. Saint-Jalmes, Victor Buzura, Yann Rosamel, Sarah Hadjih, Denis Angoulvant, Emilie Collet, Fabrice Ivanes, Katia Lassouani, Mohammed Mouzouri, Djedjiga Naudin, Thibaud Genet, Jean Guillaume Dillinger, Nadhira Bennacer, Lea Cacoub, Antoine Léquipar, Baya Mahtout, Christophe Thuaire, Marina Leniliot, Emilie Tachot, Corine Thobois, Christel Vassaliere, Batric Popovic, Jessica Breistroff, Aurélie Gutehrle, Maximilien Saint-Gilles, Jeanne Varlot, Éric Durand, Delphine Béziau-Gasnier, Najime Bouhzam, Solenn Catherine, Bryan Marais, Christophe Tron, Claire Vézier, Thibaut Hemery, Claire Bouleti, Arthur Ramonatxo, Sonia Azzakani, Nathalie Berger, Céline Boucher, François Roubille, Chloé Bonneton, Gautier Desmoulin, Fabien Huet, Sandra Kahlouche, Laurent Delorme, Angélique Andrieu, Javier Molina-Martín de Nicolás, Nathalie Durand, Marion Berous, Romain André, John Elliott, C. Cruickshank, Houda El Banna, Michael Hume, Jocelyne Benatar, J. Somaratne, Diana Gatland, Danica Kistanna, Cathrine Patten, Doreen Singh, Samraj Nandra, Chuen Siang Low, Susan Vallancey, Ian Ternouth, Neelam Dalman, Aleisha Easton, Carolyn Jackson, Simon Kirkham, Nick Fisher, Jette Koelle, Charlotte McNab, David Brieger, Shahab Pathan, Imants Rubenis, S. Swe, Sohaib Virk, Graham S. Hillis, Michelle M. Bonner, Charmaine Dias, L. David Hillis, Shaun G. Goodman, Renato D. Lópes, Tabassome Simon, Harvey White, Caroline Alsweiler, Bernard Chaitman, Dean Fergusson, Erin Morton, Lilian Mazza Barbosa, Pedro Gabriel Melo de Barros e Silva, Liliane A.T. Arnaldi Seixas, Paola Engelmann Arantes, Larissa Teixeira Aleixo Silva, Georgia Beatriz Oliveira Damásio, Laurence Bérard, Alexandra Rousseau, Sandra Paco, Narimane Benhamadi, Véléda Blesboi, Marie Delon, Alexia Ep, Kaïna Mahmoudi, Katia Ledra, Irène Garcia Ramos, Marie Henault, Alexia Dantigny, A. Kone, Djouher Firoud, Véronique Pignot, Élodie Drouet, Eunice Nubret, Margot Bobin, Christophe Aucan, Lauren Demerville, Serge Bureau, Maria Pina Simula, Derek P. Chew, Yogesh Sharma, C. Hincks, Ivana Hunt, Simeoni Thomas, Fiona Wollaston, Brandon M. Herbert, M. Lombardero, R. Mercurio, Jennifer C. Stevenson, Donna Stoliker, Ella Zadorozny, Jane Eckstein, Simone A. Glynn, Eric Leifer, Erin N. Smith, George Sopko, Phil Tonkins, Pablo Cure, Catherine Levy, Naomi L.C. Luban, Barbara A. Konkle, Deepak Bhatt, Eldad A. Hod, Cassandra D. Josephson, KyungMann Kim, Agnes Lee, Leslie Serchuck, Peter Stone, Darby Thompson, Kathryn L. Weise
Notice bibliographique
RevueJAMA Network Open · 2024
Typearticle
Langueen
DomaineMedicine
ThématiqueErythropoietin and Anemia Treatment
Établissements canadiensHealth Sciences CentreSunnybrook Health Science CentreUniversity of TorontoSt. Michael's HospitalUniversité de MontréalCentre Hospitalier de l’Université de Montréal
Organismes subventionnairesNational Heart, Lung, and Blood InstituteInstitute of Circulatory and Respiratory HealthCanadian Institutes of Health ResearchAgence Nationale de la RechercheCanadian Blood Services
Mots-clésMedicineAnemiaRandomizationMyocardial infarctionRandomized controlled trialInternal medicinePediatrics
Résumé
Importance: In patients with acute myocardial infarction (MI), limited physiologic adaptation to acute anemia might lead to greater benefit from a liberal red blood cell (RBC) transfusion strategy. Data on such a possible benefit are lacking. Objectives: To compare acute anemia with chronic anemia and post-MI outcomes and estimate the differential effect of a restrictive RBC transfusion strategy compared with a liberal strategy on post-MI outcomes according to anemia acuity. Design, Setting, and Participants: A prespecified subgroup analysis of the Myocardial Ischemia and Transfusion (MINT) multicenter randomized clinical trial was conducted in 126 hospitals in 6 countries between April 26, 2017, and April 14, 2023, with 30-day follow-up and blinded adjudication of the primary outcome. The analysis included 3144 of 3504 MINT participants (89.7%) with acute MI, a hemoglobin (Hb) level less than 10 g/dL at randomization, and a first Hb measurement available on the day of or the day following hospital admission. Intervention: The MINT trial randomized participants to a restrictive (Hb <7-8 g/dL) or liberal (Hb <10 g/dL) RBC transfusion strategy. Acute anemia was defined as having a first Hb value greater than 13 g/dL (men) or 12 g/dL (women), or as having a decrease greater than or equal to 2 g/dL between the first Hb measurement and measurement at randomization. Other Hb levels were categorized as chronic anemia. Main Outcomes and Measures: The primary outcome was a composite of death or recurrent MI up to 30 days after randomization. Secondary outcomes were death, recurrent MI, cardiac death, heart failure, pulmonary complications, and major bleeding events. Intention-to-treat analysis was performed. Results: Among 3144 included participants (mean [SD] age, 72.3 [11.6] years; 1715 [54.5%] male; 1307 [41.6%] with type 1 MI), 1078 [34.3%]) had acute anemia. Acute anemia was associated with an increased risk of death or recurrent MI (adjusted risk ratio, 1.25; 95% CI, 1.05-1.48). The effect of a restrictive RBC transfusion strategy compared with a liberal strategy was similar for participants with either acute or chronic anemia for all outcomes. Conclusions and Relevance: In this secondary analysis of the MINT trial, acute anemia was associated with less favorable post-MI outcomes than chronic anemia but did not modify the effects of the randomized transfusion strategy. In patients with anemia and MI, the acuity of anemia should not influence the choice of transfusion trigger. Trial Registration: ClinicalTrials.gov Identifier: NCT02981407.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
score de la tête « metaresearch » (Codex)0,001
score de la tête « metaresearch » (Gemma)0,000
Version: codex-gemma-dda1882f352aStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Observationnel · Signal consensuel: aucune
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,737
Score d'incertitude au seuil0,591
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
Tête enseignante Opus0,013
Tête enseignante GPT0,313
Écart entre enseignants0,300 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validation
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Les modèles n’ont appliqué aucune catégorie : rien dans la taxonomie ne correspondait à ce travail.
Devis d'étudeObservationnel
Domainenon disponible
GenreEmpirique
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».
En bref
Citations6
Publié2024
Routes d'admission2
Résumé présentoui