The Effect of Adding Stromal Vascular Fraction (SVF) to Hydrocolloid Dressing to Enhance Healing of Donor Sites of Split Thickness Skin Grafts
Notice bibliographique
Résumé
Abstract Background Wound healing is complex process, which requires suitable environment to enhance the healing process. With the advancement in technology, many new wound dressings have been introduced for use on split-thickness skin graft donor sites to treat different types of wounds by targeting various aspects of healing process. An ideal donor site wound dressing can reduce pain, lower the risk of infection, encourage hemostasis, and accelerate the healing process. This dressing would also be simple to manage, simple to apply in the operating room, and affordable. The use of hydrocolloid dressing to promote healing of donor site of STSG is a well-established technique. Aim of the Work The main aim of this study was to evaluate the effect of adding Stromal Vascular Fraction (SVF) to Hydrocolloid Dressing to enhance reepithelization and quality of scars of donor Sites of Split Thickness Skin grafts. Patients and Methods Twenty-seven post burn and post traumatic patients admitted to plastic, burn and maxillofacial department in Ain Shams University hospitals which need coverage with STSG were included in this study. A prospective comparative interventional self-controlled clinical study was conducted on donor sites of STSG, In which donor sites of STSG were divided into two equal halves where the upper half was injected intradermally with SVF with application of hydrocolloid dressing (group A), and the other half was covered with hydrocolloid dressing only (group B).follow up of reepithelization at donor sites were evaluated at day 10th, 15th, 21th and 1 month post harvesting of STSG also Vancouver scar scale was used to assess the quality of the scar after 1 month. Results The result showed that among the studied population 51.9% were males and 48.2% were females with mean age of the study population was 33.37 ± 9.55 years ranged from 18 to 52 years. 85.2% of patients had burn raw areas, while only 14.8% had post-traumatic raw areas. The comparison between (group A) and (group B) according to time for reepithelization by days, we found that (group B) needed more time for healing by (18.56 ± 4.69) compared to (group A) which need (11.33 ± 1.92) days and this difference was statistically significant as p-Value <0.05. Also using Vancouver scar scale to assess the quality of scar, there was statistically significant difference between both (group A) and (group B) as (p-value = <0.001). Among study cases, there were only two cases (7.41%) where complicated by superficial infection, which settled in both halves of each case, was improved on repeated dressing. Conclusion The intradermal injection of SVF in donor site resulted in significant reduction in healing time, increased epithelium thickness and a significant improvement in scar quality with low rate of infection.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».