Predictors of tuberculosis treatment outcome at Senkatana clinic in Lesotho
Notice bibliographique
Résumé
Introduction: tuberculosis (TB) is one of the top ten causes of death and the leading cause from a single infectious agent called Mycobacterium tuberculosis. This study aims to evaluate TB treatment outcomes among patients on first-line anti-tuberculosis treatment and identify the factors associated with successful TB treatment outcomes at Senkatana TB clinic in Lesotho from 2015-2017. Methods: a registry-based retrospective cohort study of all TB first-line cases recorded from 2015 to 2017 was conducted at Senkatana TB clinic. Data were captured and cleaned in Epi info version 7, and exported into Stata version 14 for analysis. Bivariate logistic regression analysis was used to determine factors associated with TB treatment outcome with p-value <0.05 indicating statistical significance. Results: a total of 1,027 TB patients were registered between 2015 and 2017. Of these, 602 (58.6%) were males and 425 (41.4%) were females, with a mean age of 39 years (SD ±12.5). A total of 843 (82.1%) patients were co-infected with HIV, of which 92.3% (n=778) were on anti-retroviral therapy (ART). The analysis of HIV co-infected with TB patients by age showed that the TB/HIV co-infection rate varies with age (p<0.001). Overall treatment success rate was at 73.4% (n= 754) and 273 (26.6%) had poor treatment outcomes, and 118 (11.5%) patients died. The odds of successful TB treatment outcome were higher in females than males (78.1% vs 70.1%, OR 1.52, 95% CI: 1.14 - 2.03, p=0.004). With regards to age, the odds of successful TB treatment outcome were higher for the 20-24 years age group (88.2% vs 65.3%, OR 3.98, 95% CI: 1.42 - 11.22, P=0.009) and 55-59 years (91.7% vs 65.3%, OR 5.84, 95% CI: 1.56 - 21.88, P=0.009), compared to ≥ 65 years age group. In addition, successful TB treatment outcomes were higher among HIV co-infected TB patients who were taking ART during TB treatment than those not taking ART (75.8% vs 23.8%, OR 11.70, 95% CI: 6.40 - 21.43, P<0.001). Patients observed by family members or friends were more likely to develop treatment success (aOR: 1.87, 95% CI: 1.13 - 3.08). Factory workers in high-risk groups had successful treatment outcomes (aOR: 1.77, 95% CI: 1.04 - 3.01). Conclusion: tuberculosis treatment success rate was low and constant over the period of three years. Death rate, loss to follow, and not evaluated were high among our study participants and above the World Health Organization (WHO) target. In unadjusted analyses, female sex, younger age, HIV co-infected taking ART, having a treatment observer, and belonging to high-risk groups, were significantly associated with successful TB treatment outcome.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».