Long-Term Outcomes of Patients with Isolated Sub-Segmental Pulmonary Embolism Managed without Anticoagulant Therapy
Notice bibliographique
Résumé
Introduction: The management of patients with isolated sub-segmental pulmonary embolism (SSPE) is controversial. The 2021 update of the American College of Chest physician clinical practice guidelines suggest withholding anticoagulant therapy in patients at low risk of recurrent venous thromboembolism (VTE) but to initiate anticoagulation in those at high risk of recurrent events. The SSPE prospective management cohort study, which included patients with SSPE at low risk of VTE managed without anticoagulant therapy, reported a 3-month risk of recurrent events of approximately 3%. However, the long-term risk of recurrent VTE (i.e., beyond the initial 3 months) is unknown. We sought to establish the long-term incidence rates of recurrent VTE and clinically relevant bleeding complications in this patient population. Methods: We performed a retrospective cohort study of patients included in the SSPE prospective management cohort study included at The Ottawa Hospital between 2011 and 2021. The primary outcome of the study was a major recurrent VTE occurring beyond the initial three months of follow-up. Major VTE was defined as recurrent proximal deep vein thrombosis (DVT) or pulmonary embolism (PE) (segmental or more proximal). Secondary outcomes included any recurrent VTE (including SSPE and distal DVT) and clinically relevant bleeding (combining major and clinically relevant non-major bleeding (CRNMB)) occurring beyond the initial three months of follow-up. Major bleeding and CRNMB were defined as per the International Society on Thrombosis and Haemostasis. Patients were censored at the time of the event, death, last known encounter or the end of the follow-up period (April 2024). Incidence rates along with their 95% confidence intervals (CI) for the primary and secondary outcome measures were computed by performing time-to-event analyses using the Kaplan-Meier method. Analyses were performed using SPSS 29.0 (IBM Corp.). Results: A total of 138 patients with isolated SSPE were included in the analysis. Mean age was 52.3 ± 16.6 years and 50.7% were female. The mean duration of follow-up was 6.0 years (range 0 to 13 years). Overall, recurrent major VTE occurred in 15 out of the 138 patients leading to an incidence rate of 1.93 per 100 patient-years (95% CI: 1.17-3.16). Among these, 9 patients experienced a recurrent PE (segmental or more proximal), 4 had a proximal DVT (3 lower extremity and 1 upper extremity), and 2 had both PE and DVT. Any VTE were observed in 23 out of the 138 patients, resulting in an incidence rate of 3.09 per 100 patient-years (95% CI: 2.07-4.59). Despite not being managed with anticoagulant therapy, clinically relevant bleeding was reported in 15 patients during the follow-up period, corresponding to a cumulative incidence rate of 1.88 per 100 patient-years (95% CI: 1.14-3.08). Of these, 12 patients experienced clinically relevant non-major bleeding, while 3 patients experienced major bleeding. Conclusion: The long-term incidence of VTE is relatively low in patients with isolated SSPE managed without anticoagulation, yet higher than that observed in the general population. The incidence rates of clinically relevant bleeding without anticoagulation is not negligeable. Future studies are needed to assess the risk benefit ratio of anticoagulation in this patient population.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».