MULTIPLE PRIMARY CANCERS IN LUNG CANCER PATIENTS IN ATLANTIC CANADA AND IMPLICATIONS FOR SCREENING AND MANAGEMENT
Notice bibliographique
Résumé
Abstract Background Lung cancer incidence rates in Atlantic Canada significantly exceed those of other Canadian provinces, with underlying causes remaining poorly understood. This regional disparity suggests potential genetic or environmental factors unique to Atlantic Canada. Here we present for the first-time data indicating that accompanying the high lung cancer rates in Atlantic Canada is an intricate landscape of multiple malignancies. This represents a phenomenon of multiple primary cancers that is unprecedented in the literature and presents unique challenges in the diagnosis and treatment of individuals diagnosed with lung cancer in Atlantic Canada. Methods We performed a retrospective chart review of 1,151 patients referred to the thoracic surgeons at the Queen Elizabeth II Health Sciences Centre between 2019 and 2023 with the new diagnosis of lung cancer. The primary focus was to assess the incidence of multiple primary cancers (as documented in pathology reports) and analyze demographic, clinical, and geographical factors through Fisher’s exact tests and Student’s t-tests. Results Forty-three precent (43.3%) of Atlantic Canadian patients presented with multiple primary cancers. Of 1,949 cancers identified, 1,440 were of primary lung origin. Sixty percent (60.0%) of our cohort was female. Thirty-one percent (31.3%) were self-reported current tobacco smokers, 50.3% were former tobacco smokers, and 18.4% reported no tobacco use. The average age and body mass index (BMI) at first diagnosis was similar between those patients with and without multiple primary cancers, averaging 67 years and 27.7 kg/m 2 , respectively. Thirty-nine percent (39.2%) of our study participants lived in more densely populated centers (>100,000 people), 10.2% in intermediate centers (∼98,000 people) and 50.7% in more sparsely populated centers (<55,000 people). Conclusions We have uncovered an unprecedented phenomenon in Atlantic Canada of a cohort of patients with lung cancer having multiple primary cancers of different tissue origin at a rate that is four times greater than previously described. The implications of this study are that Atlantic Canadians are disproportionately burdened with cancers of multiple origins that are not explained by smoking rates or BMI. Future studies will investigate the contribution of genetic predisposition, environmental exposures, and socioeconomic factors unique to Atlantic Canada underlying the high rates of multiple primary cancers documented here in a lung cancer cohort. Such studies will be essential to develop effective cancer prevention and screening strategies in Atlantic Canada.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».