Abstract 032: TOPSS: TOlerability of tDCS in Pediatric Stroke Survivors
Notice bibliographique
Résumé
Introduction Pediatric cerebrovascular disease is a leading cause of morbidity in children. Childhood‐onset stroke is defined as stroke occurring after the first month of life and accounts for about half of pediatric stroke. Most children with childhood‐onset stroke will survive to adulthood, but ~75% of those with childhood‐onset stroke experience long‐term neurologic impairments, including motor weakness and cognitive difficulties. Hemiparesis is a frequent complication of childhood‐onset stroke and is tremendously debilitating. Transcranial direct current stimulation (tDCS) is a promising and inexpensive non‐invasive neuromodulation technique that can be used to augment neuronal plasticity as an adjunctive rehabilitation therapy. Methods Participants with chronic hemiparesis from childhood‐onset ischemic or hemorrhagic stroke were prospectively enrolled in this study. All study participants received 5 sessions of tDCS lasting for 20 minutes each while engaging in 1‐on‐1 occupational therapy with a certified occupational therapist. tDCS sessions were followed by an additional 1 hour and 40 minutes of rehabilitation therapy focused on the impaired arm. The amplitude of stimulation was increased daily as follows: sham stimulation on day 1, 0.5mA on day 2, 1.0mA on day 3, 4, and 5. Participants aged 13‐19 years had stimulation further increased to 1.5mA on days 4 and 5. The primary objective measures were safety and tolerability which were assessed with percent study completion, participant tolerability questionnaires, and pre‐ and post‐ stimulation vital signs. Secondary outcome measures included arm function measured using the Fugl‐Meyer Assessment of the Upper Extremity (FMA‐UE) and box and blocks test. Satisfaction was measured using the Canadian Occupational Performance Measure (COPM). A data safety and monitoring board comprised of a pediatric neurologist and pediatric physiatrist reviewed all stimulation monitoring sheets. Results Five participants completed the study. Blood pressure and pulse measurements were within normal limits for all participants for all pre‐ and post‐therapy measurements. Participants reported itching sensations during 40% of tDCS sessions, with reports extinguishing within minutes after cessation of tDCS. The Fugl‐Meyer Assessment of the Upper Extremity is a functional scale with a score range of 0 (profound hemiplegia) to 66 (no impairment). An improvement of 5 points may be considered clinically significant. The median score was 35 at the pre‐therapy assessment, and improved to 42 at the 3 month follow up. 4 out of 5 participants had a clinically significant increase in the Fugl‐Meyer Assessment. Canadian Occupational Performance Measure performance score was 4 at baseline and improved to 6.4 at 3 month follow up. Conclusion tDCS was well‐tolerated in this pilot study of tDCS in participants with chronic hemiparesis from childhood‐onset stroke. There were no major adverse events, and the most common reported side effects were mild itching or tingling which did not limit participation. Fugl‐Meyer Assessment of the Upper Extremity scores improved an average of 7 points 3 months post therapy. Further research with larger, double‐blinded, sham controlled studies is needed. We will continue further research into the utility of tDCS for childhood‐onset stroke with a single center, double‐blinded, randomized controlled trial of tDCS vs sham with a goal enrollment of 20 participants.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».