P0711 The Effect of Extraintestinal Manifestations Presence on Treatment Persistence in IBD Treatment
Notice bibliographique
Résumé
Abstract Background Inflammatory Bowel Disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. A significant portion of patients also experience extra-intestinal manifestations (EIMs) that involve various organ systems beyond the intestines. EIMs are often present at the onset of disease or may develop later during the course of IBD, and their severity can vary, influencing overall disease prognosis and quality of life. Effective management of IBD requires a holistic approach that not only addresses the intestinal inflammation but also anticipates and treats these extra-intestinal complications. In this study we aimed to investigate the role of EIM presence on anti-TNF treatment persistence in IBD therapy. Methods This was a single center, retrospective cohort analysis of patients with IBD either received adalimumab or infliximab as a first line biologic treatment. A total of 673 patients were included to this analysis. Demographic information such as gender, age, Montreal classification, EIM presence, smoking and prior medications were noted from patients electronic medical records. Weighted Kaplan-Meier and Cox models were used to assess the outcomes. Results Out of 673 patients, 426 patients had Crohn’s disease, 240 patients had ulcerative colitis and 7 patients had indeterminate colitis. Overall, 379 pateints received adalimumab and 294 patients received infliximab as first line biologic treatment for IBD. While 272 patients had EIM, 349 patients did not have EIM accompanying their IBD. EIM presence was not concluded in 52 patients from their medical charts. Smoking and family history were not different between patiemnts with and without EIM. However, female patients had statistically more EIM (51.3% vs. 38.1%, p<0.05) and patients with Crohn’s disease had statistically more EIM (49.4% vs 34.5%, p<0.05). Anti-TNF drug persistence was significantly higher in patients with EIM when compared to patients with no EIM (Figure 1). This difference was independent of the type of anti-TNF medication used. However, in patients with ulcerative colitis the difference became more significant, while in Crohn’s disease patients although there is trend, the difference was not significant. The concomitant use of immunomodulator drugs did not make any impact. Conclusion In IBD patients, anti-TNF medication persistence was observed to be significantly longer in those with EIM. This difference was significantly greater in ulcerative colitis patients compared to Crohn’s patients. This difference was independent of the concomitant medication use.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».