The effect of dietary camelina, flaxseed, and canola oil supplementation on skin fatty acid profile and immune and inflammatory responses in healthy adult horses
Notice bibliographique
Résumé
Camelina sativa is an oilseed crop rich in α-linolenic acid (ALA), an n-3 fatty acid (FA), and is resistant to harsh climates and pests. Previously, supplementation with camelina oil (CAM) in horses had no adverse effects on basic health parameters and had comparable skin and coat parameters as both flaxseed oil (FLX) and canola oil (OLA). Further, the plasma FA profile of horses was reflective of their respective treatment oil. The objective of this study was to assess the effects of dietary CAM supplementation on skin FA profile, immune, and inflammatory responses as compared to 2 commonly used oils in the equine industry, OLA and FLX, in healthy adult horses. Twenty-four adult horses, from 2 separate herds, were enrolled in this experiment. The horses underwent a gradual 4-wk fat acclimation period to sunflower oil (approximately 0.28% ALA), then were supplemented with either CAM (approximately 34.9% ALA), OLA (approximately 12.0% ALA), or FLX (56.0% ALA) at an inclusion rate of 0.37 g/kg body weight (BW) per day for an additional 16 wk. Immune and inflammatory responses were assessed by measuring antibody concentrations across time after sensitization to keyhole limpet hemocyanin (KLH) at weeks 10 and 12, and a subsequent delayed-type hypersensitivity (DTH) challenge. Skin biopsy samples were collected at weeks 0, 8, and 16, and FA composition was determined using gas-chromatography. All data were analyzed as a repeated measures ANOVA using PROC GLIMMIX in SAS. Antibody and DTH responses to KLH did not differ among groups (P = 0.262 and 0.813, respectively), and no treatment by time effects were observed (P = 0.764 and P = 0.817, respectively). Most FA in the skin changed in composition across time, with the sum of n-3 FA increasing (P < 0.001) and the sum of n-6 FA and skin n-6:n-3 ratio decreasing over time (P < 0.001 and P < 0.001, respectively). Only dihomo-γ-linolenic acid (P = 0.025) and the sum of n-3 FA (P = 0.031) had treatment-by-week effects. At week 16, the composition of eicosapentaenoic acid in the skin was greater in FLX than OLA, but neither differed from CAM (P = 0.049). These results suggest that ALA supplementation may beneficially impact skin FA profile. However, due to the small differences in n-3 FA and n-6:n-3 ratio among CAM, FLX, and OLA, a comparable skin FA profile, immune, and inflammatory response was observed among treatments at a dose of 0.37 g oil/kg BW. Therefore, CAM may be a suitable alternative to FLX in equine diets for the delivery of ALA.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».