Selected Articles from This Issue
Notice bibliographique
Résumé
Most polygenic risk scores (PRS) for breast cancer have been developed specifically in women of European ancestry. In this study, Huang and colleagues assessed the latest PRS panels developed in populations of European and Asian ancestry in combined analyses of multiple Hispanic/Latinx studies from different countries and with different proportions of genetic ancestry. Results suggest that it is more important to discover ancestry-specific variants and add them to existing models than to refine existing models by ancestry proportions of individuals. This approach has the important practical advantage of making the implementation of PRS in clinical settings more straightforward without worrying about estimating the genetic ancestry portions of individuals.In Canada, colorectal cancer is the third most frequently diagnosed cancer, but the relationship between socioeconomic status and colorectal cancer screening in Canada remains poorly understood. This study by Jalili and colleagues aimed to measure and explain the extent of socioeconomic inequalities in colorectal cancer screening participation in Ontario, Canada among adults aged 50 to 74 years utilizing cross-sectional data from the 2017 to 2018 Canadian Community Health Survey. The study found that income is the primary driver of socioeconomic inequality, requiring targeted strategies to boost screening rates among low-income residents. Results suggest that addressing education and language barriers through awareness initiatives and language support can reduce socioeconomic inequalities in cancer screening uptake in Ontario.Comparisons of nicotine and toxicant exposure between people who use different alternative tobacco products remain underexplored. This cross-sectional, multi-country study by Miller and colleagues analyzed urinary metabolites of nicotine, NNK, and volatile organic compounds among established users in Japan and Canada. Exclusive use of alternative tobacco products results in significant nicotine exposure but substantially lower toxicant exposure compared to exclusive combustible cigarettes use. Exposure patterns between two popular alternative tobacco products differ. People who use heated tobacco products in Japan may experience higher exposure to nicotine and certain toxicants than people who use nicotine vaping products in Canada. The overall toxicant exposure from alternative tobacco products is lower than combustible cigarettes, providing critical data for regulatory decisions and public health considerations.The growing population of male adolescent and young adult cancer survivors has increased interest in their reproductive health. However, studies have reported conflicting findings on the potential risks of cancer and its treatments on birth and obstetric outcomes. This study by Kao and colleagues aims to investigate whether a paternal history of cancer during adolescence or young adulthood is associated with adverse outcomes in the offspring. This nationwide, retrospective, population-based cohort study integrated data from three major Taiwanese databases. Results show that paternal cancer history during adolescence or young adulthood does not appear to increase offspring’s risk of adverse birth or obstetric outcomes. This study provides valuable insights for oncology and reproductive medicine, potentially influencing patient counseling and guidelines.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,010 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,002 | 0,001 |
| Bibliométrie | 0,004 | 0,003 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,006 | 0,003 |
| Science ouverte | 0,002 | 0,002 |
| Intégrité de la recherche | 0,003 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,615 | 0,413 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; l’étiquette directe de Gemma et le classifieur distillé Codex s’accordent sur ce qui est montré ici.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».