A185 ERYTHEMA NODOSUM AS A MARKER FOR OBJECTIVE DISEASE ACTIVITY IN INFLAMMATORY BOWEL DISEASE: A SINGLE CENTER RETROSPECTIVE STUDY
Notice bibliographique
Résumé
Abstract Background Erythema Nodosum (EN) is an inflammatory condition characterized by tender, erythematous nodules, typically found on the extensor surfaces of the extremities. EN is linked to both immune-mediated conditions, such as inflammatory bowel disease (IBD), Behçet’s syndrome, and sarcoidosis, as well as non-immune-mediated conditions. In patients with IBD, EN affects 3–10% of those with ulcerative colitis (UC) and 4–15% with Crohn’s disease (CD), particularly in patients with colonic involvement. While EN has been thought to be associated with disease activity, this conclusion has been primarily based on symptom assessment, and a definitive association with objective measures, such as inflammatory markers or endoscopic activity, has not yet been established. Aims To investigate the association of EN to objective inflammatory assessments among IBD patients. Methods Using the IBD Center of British Columbia database, patients with active EN were assessed. For each patient, disease activity based on symptoms was evaluated. Objective assessments, such as colonoscopy and imaging modalities such as CT, MR, or video capsule enterography, were included if they were performed within a three-month window of the EN presentation. Fecal calprotectin and C-reactive protein (CRP) were collected if obtained within four weeks of the EN presentation, using thresholds of 250 µg/g and 5 mg/L respectively. Standard descriptive analyses were conducted to evaluate any association between both objective and subjective measures of disease activity and the presence of EN. Results The initial search identified 165 patients with a documented presentation of EN. The mean age at presentation of EN was 40 years. The majority of EN patients had Crohn’s disease (89, 76%), and were predominantly female (86, 74%). Among those, 116 patients had at least one objective assessment within the prespecified time with 71 patients (61%) having a colonoscopy as a sole method to identify disease activity, while CRP, imaging, and fecal calprotectin were used in 28 (24%), 10 (9%), and 7 (6%) of the cases, respectively. In regards to disease activity, 68 (58%) patients had gastrointestinal symptoms at the time of EN presentation. However, out of 116 cases, a total of 93 (80%) had objective evidence of active disease. Conclusions In this analysis of IBD patients with active EN, objective evidence of intestinal disease activity was found in a significant majority (80%) of cases, despite only 58% of patients reporting gastrointestinal symptoms at the time of EN presentation. These findings suggest that EN may be closely associated with underlying intestinal inflammation even in the absence of overt clinical symptoms. This highlights the potential importance of pursuing objective assessments in patients who present with EN, even with no overt clinical symptoms. Funding Agencies None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».