A194 PATTERNS OF INFLAMMATORY BOWEL DISEASES IN NORTHWESTERN ONTARIO
Notice bibliographique
Résumé
Abstract Background Geographic disparity adds to the challenges of caring for patients with inflammatory bowel disease (IBD) in Canada. Northwestern Ontario is one of the least densely populated regions among Canadian provinces, with limited existing research examining patients affected by IBD. Aims We sought to 1) describe the clinical trends and characteristics of patients with IBD in Northwestern Ontario and 2) compare the course of disease among patients residing in urban versus rural areas. Methods Thunder Bay is the major site for specialized care in Northwestern Ontario, allowing for the inclusion of approximately all IBD patients in the region. This retrospective study involved data collected over a 25-year period from January 1, 1999 to October 1, 2024. Northwestern Ontarians with diagnostic confirmation of IBD were included. Deceased patients were excluded. Participants were identified using billing codes and keywords from electronic records of three gastroenterologists practicing at the Thunder Bay Regional Health Sciences Centre, the only tertiary care centre in Northwestern Ontario. Data were collected from clinic and hospital records. Student’s t-test and chi-squared test were used in statistical analysis. Results Among 2115 patients who were screened, this preliminary analysis identified 1061 IBD patients, including 546 (51.5%) with ulcerative colitis, 481 (45.3%) with Crohn’s disease, and 34 (3.2%) with unclassified colitis. Mean age was 52.6±17.3 years and 49.9% were female. Mean age at diagnosis was 36.2±17.0 years and median time to diagnosis was 5 months. There were significantly more smokers among patients with Crohn’s. Based on the last clinical encounter, 692 (65.2%) patients were in clinical remission, 174 (16.4%) were in active disease, and 186 (17.5%) were lost to follow up. Current medications included biologics (369, 34.8%), 5-ASA (366, 34.5%), immunomodulators (119, 11.2%), and glucocorticoids (71, 6.7%). Throughout the course of disease, mean number of Emergency Department visits and hospital admissions were 2.6±4.7 and 1.2±2.4 respectively, and 325 (30.6%) patients underwent IBD-related surgery. The cohort included 752 (70.9%) urban residents and 309 (29.1%) rural residents. No significant difference was observed between urban and rural residents, including age, sex, disease type, prevalence of biologic use, disease severity based on the Montreal classification, or current disease status. Conclusions This study characterizes the patient population and clinical trends of IBD in a low population density region in Ontario. There appears to be homogeneity between rural and urban residents, with comparable patient and disease features, and access to medications including biologics. Funding Agencies None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,003 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».