A176 SEROLOGICAL HEAVY METAL ASSESSMENT IN PERSONS WITH IBD
Notice bibliographique
Résumé
Abstract Background Inflammatory Bowel Disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic conditions of aberrant gut inflammation. The increasing prevalence of IBD in parallel with increasing human exposure to heavy metals (HMs) has raised concern regarding the contribution of HMs to gut pathology. Emerging evidence has implicated HMs as influential factors in IBD pathogenesis, however, our current understanding of how HMs impact gut barrier integrity, inflammation, and dysbiosis is limited in the context of IBD and deserving of further attention. Aims The preliminary study aim was to establish a foundational understanding of serum levels of certain HMs in IBD. Additionally, we aimed to characterize a correlation between HM concentrations in serum and gut tissue. Methods Using Inductively Coupled Plasma Mass Spectrometry (ICP-MS), serum concentrations of Aluminum (Al), Chromium (Cr), Mercury (Hg), and Titanium (Ti) were measured in individuals with CD, UC, multiple sclerosis (MS), and in healthy controls (HC), where MS was used as an immune-mediated inflammatory disease control. A bivariate analysis was used to evaluate associations between HM levels and specific disease groups. Logistic regression analysis was used to assess HM outcomes predicted by disease groups and healthy controls while controlling for demographic factors. Results Relative to HCs, the proportion of higher serum levels of Al (79% vs. 38.6%, p<0.001), and Hg (63% vs 37.2%, p<0.001) were greater in CD. Whereas higher Ti levels were lower in CD (59%), UC (14.0%), and MS (6.1%) relative to HCs (84.1%); p-values <0.0002, <0.0001, and 0.001 respectively. In MS, the proportion of higher levels of Cr were greater compared to HCs (83.7% vs 38.0%, p<0.001) and Hg (57.1% vs 37.2%,p=0.025).When controlling for demographic factors, the odds of having higher serum Al (OR=6.41[CB1], 95%CI 3.04-13.5) and Hg (OR=2.27, 95%CI 1.13-4.57) were significantly greater in CD relative to HCs. In contrast, the odds of having elevated serum Ti were significantly lower in CD (OR=0.25, 95%CI 0.11-0.57) and UC (OR=0.02, 95%CI 0.01-0.08) relative to HCs. The odds of having increased Cr were 12 times greater for MS relative to HC [OR=12.33, 95%CI (3.83-39.7)]. In our investigation of gut biopsies, we did not find a correlation between HM levels in serum and intestinal tissue. Conclusions Our investigation demonstrated significant differences in serum HM levels between CD, UC, MS, and HCs. These results support the need for further exploration into the specific involvement of HMs in IBD. Funding Agencies None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».