A124 CHARACTERISTICS OF GASTRIC CANCER IN BRITISH COLUMBIA
Notice bibliographique
Résumé
Abstract Background Gastric cancer remains a significant global health concern. In Asia, the prevalence of H. Pylori (HP) infection has led to well described risk factors in a more homogenous populace. In contrast, British Columbia presents a more diverse population, yet there is limited data on the specific characteristics of gastric cancer in this region. Aims 1. Compare the distribution and characteristics of histological types of gastric cancer using both the Lauren and Japanese classification. 2. Compare early-stage gastric cancers (T1) and advanced stages, focusing on the effectiveness of early detection and treatment approaches. Methods We conducted a retrospective analysis of patients diagnosed with gastric cancer between 2012 and 2024 from 5 major centers in the Greater Vancouver area. This includes patients from the interior of British Columbia. Patients with gastroesophageal junction (GEJ) or gastric cardia lesions were excluded. For each patient, demographic data (including ethnicity), lesion characteristics, and risk factors were collected. HP positivity was confirmed by histological inspection or a prior positive non-invasive test. Data were analyzed using standard stastical methods. Results The initial search identified 297 patients, with 167 meeting the inclusion criteria (mean age 68 years, male 62%, diffuse histology 46%, surgical resection 93%, H. pylori positive 40%). Patients with intestinal-type gastric cancer were more likely to be male (77% vs. 49%), older (mean age 72 years vs. 63 years), and had higher rates of background atrophic gastritis (68% vs. 34%). Intestinal-type patients were more likely to meet criteria for endoscopic resection (17% vs. 2%). There were no significant differences in ethnicity or HP status between the histological subtypes. Tumor size approached significance, with intestinal-type cancers tending to be smaller (3.9 cm vs. 5.0 cm, p = 0.067). Early gastric cancer represented 22% of the cohort. Among these, 41% met criteria for endoscopic resection, though only 3 patients actually underwent the procedure (21% of those eligible). Conclusions Gastric cancers in British Columbia are being diagnosed at a more advanced stage compared to some Asian populations, specifically in Japan. A significant proportion of patients eligible for endoscopic resection are instead undergoing surgery. Intestinal-type gastric cancers are more likely to be endoscopically resectable, likely due to more liberal resection. Patients with intestinal-type gastric cancer are also more likely to have background changes in the stomach, indicating a need for closer follow-up when this is detected. No significant ethnic differences were observed between histological subtypes. Our findings underscore the need for improved early detection strategies in British Columbia, as well as the potential to reduce unnecessary surgeries through increased use of endoscopic resection. Table. Comparison of Clinicopathological Features of Gastric Cancer Subtypes Based on Histological Type (Intestinal, Diffuse, Mixed) and Differentiation Status. Funding Agencies None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,005 |
| Études des sciences et des technologies | 0,002 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».