A217 OUTCOMES OF BALLOON ASSISTED ENDOSCOPIC STRICTURE DILATION IN PATIENTS WITH SMALL BOWEL CROHN’S DISEASE
Notice bibliographique
Résumé
Abstract Background Crohn’s Disease (CD) is a subset of inflammatory bowel disease (IBD) that has unique pharmacologic, endoscopic and surgical considerations secondary to chronic, transmural inflammation that affects the entire gastrointestinal tract. The natural history of this disease is complicated by formation of fibro-stenotic strictures, adhesions and penetrating fistulae. Balloon-assisted endoscopy (BAE) has significantly improved the ability to assess and treat small bowel CD. Aims We present a Canadian cohort of patients that have undergone BAE for stricture dilation of fibrostenotic CD. We retrospectively analyzed demographic, clinical and endoscopic risk factors that could be associated with increased risk of requiring surgical management. Methods Retrospective analysis of 157 patients undergoing BAE for stricture dilation of known CD from Apr 2012 – Jan 2024 at the University of Alberta Hospital. A total of 282 procedures were performed and 629 strictures dilated. Patients were then subdivided into two groups: patients that required surgery at any point after their first BAE compared with patients managed with balloon-assisted endoscopic stricture dilation alone. Results Of 157 patients with confirmed stricturing CD, 65/157 (41.4%) required surgery between Apr 2012- Jan 2024 and 92/157 (58.6%) patients were managed with endoscopic intervention. The average age at the time of their first BAE was 55.9 years and mean disease duration was 20.76 years in the surgery group. Average patient age in the non-surgical group was 52 years and mean disease duration was 17.9 years. 43.08% (28/65) of patients were active smokers in the surgical group vs. 26.09% (24/92) in the non-surgical group. Concurrent or previous biologic use was comparable at 76.9% and 73.9% in the surgical and non-surgical groups, respectively. The average minimum diameter dilated was 15.2(+/- 0.25) mm in the surgical group vs. 16.2(+/- 0.16) mm in the non-surgical group. The incidence of non-traversable strictures post-dilation was higher in the surgical group (34/231, 14.72%) compared with the non-surgical group (16/398, 9.20%). In total, 97 surgeries were performed and average time to surgery from first BAE was 32.22 months (excluding emergent/urgent surgeries). Average time from most recent BAE to surgery was 8.79 months. There were 3 emergent surgeries (<24 hours from BAE to surgery, including one perforation) and 7 urgent surgeries (<30 days from BAE to surgery). Conclusions BAE has revolutionized endoscopic management of small bowel stricturing CD. Based on our retrospective case cohort, most patients with symptomatic strictures in the small bowel secondary to CD can be successfully managed with balloon-assisted endoscopic dilation. BAE may also play an important role in preventing emergent/unplanned surgical interventions. Funding Agencies None
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».