A218 INFLAMMATORY PHENOTYPE AS A PREDICTOR OF TREATMENT RESPONSE IN ULCERATIVE COLITIS
Notice bibliographique
Résumé
Abstract Background A variety of immune pathways contribute to the propagation of inflammation in ulcerative colitis (UC). Both, Th1- and Th2-associated cytokines and cells, have been implicated in the pathogenesis of the disease. Eosinophils, which are elicited by Th2 immune response, are increasingly recognized to have a pivotal role in the pathogenesis of UC, however, the exact link between eosinophils and UC disease outcomes and treatment responses over time is still incompletely defined. Aims We aim to evaluate the association between pre-treatment peripheral eosinophil counts and treatment response in patients with ulcerative colitis. Methods In this retrospective cohort study, data from 150 treatment naïve adult patients who were diagnosed with ulcerative colitis between 2005 and 2020 were reviewed. White blood count differential was collected at diagnosis and following exposure to one or more of the following treatments: corticosteroids, TNFa antagonists, or vedolizumab. Patients were stratified into two cohorts for analysis: “high-eosinophil” cohort (>=0.2x109cells/L) and “low-eosinophil” cohort (<0.2x109cells/L). The partial and endoscopic Mayo scores were evaluated at baseline and following treatment. Patients’ data were collected until their last gastroenterology follow-up or until surgical intervention. Demogoraphic data were summarized using descriptive statistics. Fisher’s Exact test was used to evaluate the association between eosinophil count and drug response as well as other outcomes. Results A total of 150 patients were included. 92 patients (63.3%) were included in the high-eosinophil cohort, while 58 patients (38.6%) were included in the low-eosinophil cohort. The median duration of follow-up was 78 months (IQR42.5) and 74 months (IQR45) in the high-eosinophil group and low-eosinophil group, respectively. Between the high-eosinophil group and low eosinophil group, there was no statistically significant difference in terms of steroid response (71.3%, 78.6% respectively, p=0.330), achieving steroid-free remission with TNFa antagonist (76%, 72.2% respectively, p=0.662), achieving steroid-free remission with vedolizumab (54.1%, 65.2% respectively, p=0.394), or disease refractoriness requiring more than 2 drug changes (15.4%, 8.8% respectively, p = 0.106). Conclusions This study did not show a correlation between baseline eosinophil count and response to therapy - corticosteroids, TNFa antagonist, and vedolizumab. Larger prospective studies are warranted to assess disease outcomes and treatment response to eosinophil-targeted therapy. Funding Agencies None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».