ACUTE WHITE MATTER INTEGRITY INCREASES AFTER A MODERATE DOSE OF ALCOHOL ADMINISTRATION
Notice bibliographique
Résumé
Abstract Background Chronic heavy alcohol consumption is known to harm health, while occasional light to moderate drinking may have potential benefits. However, it is unclear how modest alcohol intake affects brain structure. Aims & Objectives This study aimed to examine the white matter integrity changes after a modest dose of acute alcohol consumption using diffusion tensor imaging (DTI). Method Healthy individuals aged between 20 and 29, with ALDH2*1/*2 genotype, who understood the study and gave written informed consent were included in this study. They received an intravenous alcohol infusion using the alcohol clamp method to achieve a target blood alcohol concentration of 0.50 mg/mL. We acquired DTI data on a 3T MRI scanner at Kurihama Medical and Addiction Center and assessed self-reported clinical responses to alcohol administration (i.e., stimulus, physical, or sedative) using the visual analogue scale (VAS) at baseline (T0), 90 minutes after alcohol administration started (T1), and 90 minutes after alcohol administration ended (i.e., 180 minutes from baseline) (T2). We compared whole-brain fractional anisotropy (FA)/mean diffusivity (MD) values and FA/MD values for 48 regions of interest (ROI) extracted from the JHU-ICBM-DTI-81 white matter atlas across time using repeated-measure analysis of variance (ANOVA). Additional analyses were conducted to examine the correlation between baseline FA/MD value or FA/MD value changes and changes in behavioral VAS scores. Furthermore, we performed tract-based spatial statistics (TBSS) to compare white matter integrity between conditions (i.e., T0 vs T1, T0 vs T2, T1 vs T2). Results The study consisted of 18 participants, with an average age of 25.1 years, of which 7 (38.9%) were male. Repeated measures ANOVA showed no significant differences in the whole FA/MD or FA/MD values in any DTI ROIs among the three time points. TBSS analysis revealed no significant differences in FA/MD between T1 and T0 or T2 and T1. However, there were significant increases in FA in the cerebral white matter voxel cluster at T2 compared to T0 (37,145 voxels, p=0.001, FWE-corrected), whereas no significant decreases were found. Moreover, there were significant decreases in MD in the voxel clusters, including right anterior corona radiata, right inferior fronto-occipital fasciculus, corticospinal tract, left uncinate fasciculus, anterior thalamic radiation at T2 compared to T0 (>1000 voxels, p<0.05, FWE-corrected) whereas no significant increases were found. The whole FA change from T0 to T1 showed a negative correlation with the change in the sedative score from T0 to T1 (r=-0.51, p=0.03), which did not survive after the multiple comparison correction. No other significant correlations were found between whole FA/MD changes and behavioral score changes from T0 to T1 or T0 to T2. No correlation was shown between baseline FA/MD value and the FA/MD value changes or behavioral score changes from T0 to T1 or T0 to T2. Discussion & Conclusion This study indicates that a single, moderate alcohol consumption may increase the white matter integrity. However, the chronic effects of consistent moderate drinking on the brain's structure warrant further exploration.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».