Serum miR-30b is increased in Labrador Retrievers with elevated hepatic copper levels
Notice bibliographique
Résumé
Copper associated hepatitis is a hereditary disease in Labrador Retrievers with a complex genetic background. Currently, liver biopsies are needed for diagnosis and treatment monitoring. A serum-based biomarker for hepatic copper levels could provide a less invasive diagnostic approach. Circulating microRNAs (miRNAs) are increasingly studied for their diagnostic potential in hepatobiliary disease and could be utilized in assessing hepatic copper levels. Currently, information on the potential use of copper specific miRNAs in dogs is lacking. The aim of this pilot study was to identify miRNAs associated with elevated hepatic copper levels in Labrador Retrievers. Client-owned Labrador Retrievers with normal (n = 15) and elevated hepatic copper levels (n = 21) were retrospectively selected from a patient database. We performed a miRNA screening array of 277 miRNAs in blood serum from a retrospective case-control group of Labrador Retrievers with normal (n = 5) and elevated hepatic copper levels (n = 5). MicroRNAs that were upregulated in Labrador Retrievers with elevated hepatic copper in the screen, were analyzed with qPCR in a replication cohort of Labrador Retrievers with normal (n = 13) and elevated (n = 18) hepatic copper levels. Results showed that six out of the 277 serum miRNAs were significantly upregulated in elevated hepatic copper cases and these were analyzed in the replication cohort. After Bonferroni correction, cfa-miR-30b (fold-change 2.17, p-value.002) was significantly upregulated in the replication cohort. In this exploratory study, cfa-miR-30b is increased in Labrador Retrievers with elevated hepatic copper levels. This result justifies validation in an extended set of dogs, with different forms of liver disease or in other breeds with copper toxicosis. • Copper associated hepatitis in dogs has to be diagnosed and monitored through liver biopsies, which is both invasive and costly • A blood-based biomarker would be a valuable tool for diagnosis and treatment monitoring • In this pilot study microRNA levels of 277 microRNAs were screened in client-owned Labrador retrievers with normal and elevated hepatic copper levels • Upregulated microRNAs were validated in a replication cohort of Labrador Retrievers with normal and elevated hepatic copper levels. • cfa-miR-30b was significantly upregulated in Labrador retrievers with hepatic copper accumulation and a potential blood-based diagnostic biomarker
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».